FEATURES OF METABOLISM AND THE POTENTIAL ROLE OF NEUROTROPHIC FACTORS OF THE BRAIN IN THE REHABILITATION PROCESS

Abstract

Understanding the metabolic pathways of regulation and interaction of neurotrophic factors is interesting from the point of view of discussing neurotrophic factors as biological markers reflecting the dynamics and effectiveness of the rehabilitation process. The purpose was to analyze the features of production, metabolism, mechanisms of action of neurotrophic factors, which can explain the possibility of active involvement of the main neurotrophic factors in the rehabilitation process. The article presents an analysis of the literature on the metabolism of brain-derived neurotrophic factors (brain growth factor BDNF, neurotrophins NT-3 and NT4/5, fibroblast growth factor FGF-1 and FGF-2, nerve growth factor NGF, insulin-like growth factor IGF1, glial neurotrophic factor GDNF, ciliary neurotrophic factor CNTF). Information is given about the features of their production, the relationship between profactors and mature forms, as well as the specifics of interaction with receptors. Conclusion. A statistically significant drop in the levels of neurotrophic factors during the rehabilitation therapy of children with cerebral palsy using the «exohand-2» software and hardware complex reflects the active involvement of neurotrophic factors in these processes. The spectrum of biological effects of neurotrophic factors allows us to consider the entire multicomponent mechanism that occurs in the brain in the process of functional restructuring as sufficient for rehabilitation recovery.

Keywords

• neurotrophic factors
• cerebral palsy
• rehabilitation therapy