Acetylation regulates ribonucleotide reductase activity and cancer cell growth

Guo Chen; Yin Luo; Kurt Warncke; Youwei Sun; David S. Yu; Haian Fu; Madhusmita Behera; Suresh S. Ramalingam; Paul W. Doetsch; Duc M. Duong; Michael Lammers; Walter J. Curran; Xingming Deng

doi:10.1038/s41467-019-11214-9

Nature Communications (Jul 2019)

Acetylation regulates ribonucleotide reductase activity and cancer cell growth

Guo Chen,
Yin Luo,
Kurt Warncke,
Youwei Sun,
David S. Yu,
Haian Fu,
Madhusmita Behera,
Suresh S. Ramalingam,
Paul W. Doetsch,
Duc M. Duong,
Michael Lammers,
Walter J. Curran,
Xingming Deng

Affiliations

Guo Chen: Departments of Radiation Oncology, Emory University School of Medicine and Winship Cancer Institute of Emory University
Yin Luo: Department of Pharmacology, Emory University School of Medicine and Winship Cancer Institute of Emory University
Kurt Warncke: Department of Physics, Emory University
Youwei Sun: Departments of Radiation Oncology, Emory University School of Medicine and Winship Cancer Institute of Emory University
David S. Yu: Departments of Radiation Oncology, Emory University School of Medicine and Winship Cancer Institute of Emory University
Haian Fu: Department of Pharmacology, Emory University School of Medicine and Winship Cancer Institute of Emory University
Madhusmita Behera: Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute of Emory University
Suresh S. Ramalingam: Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute of Emory University
Paul W. Doetsch: Laboratory of Genome Integrity and Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health
Duc M. Duong: Department of Biochemistry, Emory University School of Medicine
Michael Lammers: Institute of Biochemistry, Synthetic and Structural Biochemistry, University of Greifswald
Walter J. Curran: Departments of Radiation Oncology, Emory University School of Medicine and Winship Cancer Institute of Emory University
Xingming Deng: Departments of Radiation Oncology, Emory University School of Medicine and Winship Cancer Institute of Emory University

DOI: https://doi.org/10.1038/s41467-019-11214-9
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 16

Abstract

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Ribonucleotide reductase (RNR) catalyzes the de novo synthesis of deoxyribonucleoside diphosphates to provide dNTP precursors for DNA synthesis. Here the authors show that the availability of dNTPs, DNA replication, and cellular proliferation, are modulated by acetylation and deacetylation of RRM2 by KAT7 and Sirt2 respectively.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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