Potential SARS-CoV-2 Preimmune IgM Epitopes

Velizar Shivarov; Velizar Shivarov; Peter K. Petrov; Anastas D. Pashov

doi:10.3389/fimmu.2020.00932

Frontiers in Immunology (Apr 2020)

Potential SARS-CoV-2 Preimmune IgM Epitopes

Velizar Shivarov,
Velizar Shivarov,
Peter K. Petrov,
Anastas D. Pashov

Affiliations

Velizar Shivarov: Laboratory of Clinical Immunology and Department of Clinical Hematology, Sofiamed University Hospital, Sofia, Bulgaria
Velizar Shivarov: Faculty of Biology, Sofia University, Sofia, Bulgaria
Peter K. Petrov: Department of Analysis, Geometry and Topology, Institute of Mathematics and Informatics, Bulgarian Academy of Sciences (BAS), Sofia, Bulgaria
Anastas D. Pashov: Department of Immunology, Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences (BAS), Sofia, Bulgaria

DOI: https://doi.org/10.3389/fimmu.2020.00932
Journal volume & issue: Vol. 11

Abstract

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While studying the human public IgM igome as represented by a library of 224,087 linear mimotopes, three exact matches to peptides in the proteins of SARS-CoV-2 were found: two in the open reading frame 1ab and one in the spike protein. Joining the efforts to fast track SARS-CoV-2 vaccine development, here we describe briefly these potential epitopes in comparison to mimotopes representing peptides of SARS-CoV, HCoV 229E and OC43.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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