Nature Communications (Jan 2018)
Phylogenomics and antimicrobial resistance of the leprosy bacillus Mycobacterium leprae
- Andrej Benjak,
- Charlotte Avanzi,
- Pushpendra Singh,
- Chloé Loiseau,
- Selfu Girma,
- Philippe Busso,
- Amanda N. Brum Fontes,
- Yuji Miyamoto,
- Masako Namisato,
- Kidist Bobosha,
- Claudio G. Salgado,
- Moisés B. da Silva,
- Raquel C. Bouth,
- Marco A. C. Frade,
- Fred Bernardes Filho,
- Josafá G. Barreto,
- José A. C. Nery,
- Samira Bührer-Sékula,
- Andréanne Lupien,
- Abdul R. Al-Samie,
- Yasin Al-Qubati,
- Abdul S. Alkubati,
- Gisela Bretzel,
- Lucio Vera-Cabrera,
- Fatoumata Sakho,
- Christian R. Johnson,
- Mamoudou Kodio,
- Abdoulaye Fomba,
- Samba O. Sow,
- Moussa Gado,
- Ousmane Konaté,
- Mariane M. A. Stefani,
- Gerson O. Penna,
- Philip N. Suffys,
- Euzenir Nunes Sarno,
- Milton O. Moraes,
- Patricia S. Rosa,
- Ida M. F. Dias Baptista,
- John S. Spencer,
- Abraham Aseffa,
- Masanori Matsuoka,
- Masanori Kai,
- Stewart T. Cole
Affiliations
- Andrej Benjak
- Global Health Institute, Ecole Polytechnique Fédérale de Lausanne
- Charlotte Avanzi
- Global Health Institute, Ecole Polytechnique Fédérale de Lausanne
- Pushpendra Singh
- Global Health Institute, Ecole Polytechnique Fédérale de Lausanne
- Chloé Loiseau
- Global Health Institute, Ecole Polytechnique Fédérale de Lausanne
- Selfu Girma
- Armauer Hansen Research Institute
- Philippe Busso
- Global Health Institute, Ecole Polytechnique Fédérale de Lausanne
- Amanda N. Brum Fontes
- Laboratory of Molecular Biology Applied to Mycobacteria, Oswaldo Cruz Institute
- Yuji Miyamoto
- Leprosy Research Center, National Institute of Infectious Diseases
- Masako Namisato
- AUEN Polyclinic
- Kidist Bobosha
- Armauer Hansen Research Institute
- Claudio G. Salgado
- Laboratório de Dermato-Imunologia, Instituto de Ciências Biológicas, Universidade Federal do Pará
- Moisés B. da Silva
- Laboratório de Dermato-Imunologia, Instituto de Ciências Biológicas, Universidade Federal do Pará
- Raquel C. Bouth
- Laboratório de Dermato-Imunologia, Instituto de Ciências Biológicas, Universidade Federal do Pará
- Marco A. C. Frade
- Dermatology Division, Ribeirão Preto Medical School, University of São Paulo
- Fred Bernardes Filho
- Dermatology Division, Ribeirão Preto Medical School, University of São Paulo
- Josafá G. Barreto
- Spatial Epidemiology Laboratory, Federal University of Pará
- José A. C. Nery
- Leprosy Laboratory, Oswaldo Cruz Institute
- Samira Bührer-Sékula
- Tropical Pathology and Public Health Institute, Federal University of Goiás
- Andréanne Lupien
- Global Health Institute, Ecole Polytechnique Fédérale de Lausanne
- Abdul R. Al-Samie
- Ministry of Health and Population, c/o National Leprosy Elimination Programme
- Yasin Al-Qubati
- Ministry of Health and Population, c/o National Leprosy Elimination Programme
- Abdul S. Alkubati
- Ministry of Health and Population, c/o National Leprosy Elimination Programme
- Gisela Bretzel
- Division of Infectious Diseases and Tropical Medicine, University Hospital, Ludwig-Maximilians-University
- Lucio Vera-Cabrera
- Laboratorio Interdisciplinario de Investigación Dermatológica, Servicio de Dermatología, Hospital Universitario, Universidad Autónoma de Nuevo León
- Fatoumata Sakho
- Programme National Lèpre de Guinée
- Christian R. Johnson
- Centre Interfacultaire de Formation et de Recherche en Environnement pour le Développement Durable, University of Abomey-Calavi
- Mamoudou Kodio
- Centre National d’Appui à la Lutte Contre la Maladie
- Abdoulaye Fomba
- Centre National d’Appui à la Lutte Contre la Maladie
- Samba O. Sow
- Centre National d’Appui à la Lutte Contre la Maladie
- Moussa Gado
- Programme National de Lutte contre la Lèpre, Ministry of Public Health
- Ousmane Konaté
- Programme National de Lutte contre la Lèpre, Ministry of Public Health
- Mariane M. A. Stefani
- Tropical Pathology and Public Health Institute, Federal University of Goiás
- Gerson O. Penna
- Tropical Medicine Centre, University of Brasília
- Philip N. Suffys
- Laboratory of Molecular Biology Applied to Mycobacteria, Oswaldo Cruz Institute
- Euzenir Nunes Sarno
- Leprosy Laboratory, Oswaldo Cruz Institute
- Milton O. Moraes
- Leprosy Laboratory, Oswaldo Cruz Institute
- Patricia S. Rosa
- Lauro Souza Lima Institute
- Ida M. F. Dias Baptista
- Lauro Souza Lima Institute
- John S. Spencer
- Department of Microbiology, Immunology, and Pathology, Colorado State University
- Abraham Aseffa
- Armauer Hansen Research Institute
- Masanori Matsuoka
- Leprosy Research Center, National Institute of Infectious Diseases
- Masanori Kai
- Leprosy Research Center, National Institute of Infectious Diseases
- Stewart T. Cole
- Global Health Institute, Ecole Polytechnique Fédérale de Lausanne
- DOI
- https://doi.org/10.1038/s41467-017-02576-z
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 11
Abstract
Leprosy is caused by the yet-uncultured pathogen Mycobacterium leprae. Here, Benjak et al. obtain M. leprae genome sequences from DNA extracted from patients' skin biopsies and, by analysing 154 genomes from 25 countries, provide insight into the pathogen’s evolution and antimicrobial resistance.
