FEATURES OF HEMOSTASIS IN DIFFERENT TYPES OF 24 HOURS DAY'S PROFILE OF BLOOD PRESSURE IN HYPERTENSIVE PATIENTS OF DIFFERENT AGE GROUPS

Abstract

In most patients of both groups revealed changes in hemostasis in the direction of increasing the aggregation properties of platelets. However, more pronounced trends in such changes were found in patients with insufficient blood pressure at night. Given the fact that not only in the absence of control over hypertension and failure to achieve target blood pressure levels, but also with different daily blood pressure profiles, there is a high probability of thrombotic complications. That is why it was important for us to find out the peculiarities of the state of platelet aggregation indicators depending on 24 hours day’s profile of blood pressure. To date there are only isolated reports of hemostasis in this category of individuals. We conducted such studies in middle-aged and elderly patients. The aim of the study was to identify the baseline levels of hemostasis indices depending on 24 hours day’s profile of blood pressure in middle-aged and elderly hypertensive patients. Material and methods. We performed the comparative assessment of status of hemostasis in 30 middle-aged (group I) and 30 elderly patients (group II) respectively to clarify this issue in our work. Patients of the surveyed groups were comparable in age, sex and related pathology. Control group consisted of 15 patients for every of the surveyed groups (group III the middle-aged and group IV the elderly respectively) matched with basic by age and gender. Conclusions. Thus, in hypertensive patients there is an increase in platelet activity with age which is more pronounced when stimulating ADP in non-dipper group compared to dipper. In addition in older patients the most significant changes are determined in spontaneous and adrenaline-induced aggregation compared with middle-aged patients.

Keywords

• arterial hypertension, essential hypertension, hemostasis.