Evaluation of the Diagnostic Accuracy of Carbon Nanoparticle Suspensions in Sentinel Lymph Node Biopsy of Breast Cancer: A Systematic Review and Meta-analysis

Abstract

Background and aim: The present study investigated the diagnostic accuracy of carbon nanoparticle suspensions in sentinel lymph node biopsy of breast cancer.Material and methods: The present study used the PRISMA 2020-27-item checklist. To find the studies conducted in line with the purpose of the study, PubMed, Web of Science, Scopus, Science Direct, Web of Knowledge, EBSCO, Wiley, ISI, Elsevier, Embase databases, and Google Scholar search engines were reviewed from 2013 to July 2023. Meta-analysis used effect size (sensitivity and specificity) with a 95% confidence interval. The Egger test and funnel plot checked the publication bias, and data analysis was done using STATA/MP-V.17 software.Results: Ten articles with 799 patients were reviewed. The sensitivity of carbon nanoparticle suspensions in sentinel lymph node biopsy was 91% (ES, 95%CI; 78%,100%. I2=0.00%; p=1.00). The specificity of carbon nanoparticle suspensions in sentinel lymph node biopsy was 99% (ES, 95% CI; 86%,100%. I2=0.00%; p=1.00).Conclusions: Carbon nanoparticle suspensions have the highest sensitivity and specificity in sentinel lymph node breast cancer biopsy.

Keywords

• breast neoplasms
• carbon
• nanoparticles
• sentinel lymph node biopsy