A unified strategy toward total syntheses of lindenane sesquiterpenoid [4 + 2] dimers

Abstract

Of the 3 classes of dimeric lindenane sesquiterpenoids, only type I And II have been targeted in total synthesis. Here, the authors report a unified strategy to synthetically access the 3 classes of lindenane sesquiterpenoids dimers by developing a [4 + 2] cycloaddition between a common furyl diene and various dienophiles.