Obesity and the obesity paradox in abdominal aortic aneurysm

Feng Lu; Feng Lu; Yong Lin; Yong Lin; Jianshun Zhou; Jianshun Zhou; Zhen Chen; Zhen Chen; Yingying Liu; Yingying Liu; Maolin Zhong; Maolin Zhong; Lifeng Wang; Lifeng Wang; Lifeng Wang

doi:10.3389/fendo.2024.1410369

Frontiers in Endocrinology (Jul 2024)

Obesity and the obesity paradox in abdominal aortic aneurysm

Feng Lu,
Feng Lu,
Yong Lin,
Yong Lin,
Jianshun Zhou,
Jianshun Zhou,
Zhen Chen,
Zhen Chen,
Yingying Liu,
Yingying Liu,
Maolin Zhong,
Maolin Zhong,
Lifeng Wang,
Lifeng Wang,
Lifeng Wang

Affiliations

Feng Lu: Department of Anesthesiology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China
Feng Lu: Ganzhou Key Laboratory of Anesthesiology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China
Yong Lin: Department of Anesthesiology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China
Yong Lin: Ganzhou Key Laboratory of Anesthesiology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China
Jianshun Zhou: Department of Anesthesiology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China
Jianshun Zhou: Ganzhou Key Laboratory of Anesthesiology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China
Zhen Chen: Department of Anesthesiology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China
Zhen Chen: Ganzhou Key Laboratory of Anesthesiology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China
Yingying Liu: Department of Anesthesiology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China
Yingying Liu: Ganzhou Key Laboratory of Anesthesiology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China
Maolin Zhong: Department of Anesthesiology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China
Maolin Zhong: Ganzhou Key Laboratory of Anesthesiology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China
Lifeng Wang: Department of Anesthesiology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China
Lifeng Wang: Ganzhou Key Laboratory of Anesthesiology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China
Lifeng Wang: Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou, Jiangxi, China

DOI: https://doi.org/10.3389/fendo.2024.1410369
Journal volume & issue: Vol. 15

Abstract

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Obesity, characterized by its complexity and heterogeneity, has emerged as a significant public health concern. Its association with increased incidence and mortality of cardiovascular diseases stems not only from its complications and comorbidities but also from the endocrine effects of adipose tissue. Abdominal aortic aneurysm (AAA), a chronic inflammatory condition, has been closely linked to obesity. Intriguingly, mild obesity appears to confer a protective effect against AAA mortality, whereas severe obesity and being underweight do not, giving rise to the concept of the “obesity paradox”. This review aims to provide an overview of obesity and its paradoxical relationship with AAA, elucidate its underlying mechanisms, and discuss the importance of preoperative weight loss in severely obese patients with AAA.

Published in Frontiers in Endocrinology

ISSN: 1664-2392 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology
Website: https://www.frontiersin.org/journals/endocrinology

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