Leptin receptor co-expression gene network moderates the effect of early life adversity on eating behavior in children

Randriely Merscher Sobreira de Lima; Barbara Barth; Danusa Mar Arcego; Euclides José de Mendonça Filho; Sachin Patel; Zihan Wang; Irina Pokhvisneva; Carine Parent; Robert D. Levitan; Michael S. Kobor; Ana Paula Santana de Vasconcellos Bittencourt; Michael J. Meaney; Carla Dalmaz; Patrícia Pelufo Silveira

doi:10.1038/s42003-022-03992-8

Communications Biology (Oct 2022)

Leptin receptor co-expression gene network moderates the effect of early life adversity on eating behavior in children

Randriely Merscher Sobreira de Lima,
Barbara Barth,
Danusa Mar Arcego,
Euclides José de Mendonça Filho,
Sachin Patel,
Zihan Wang,
Irina Pokhvisneva,
Carine Parent,
Robert D. Levitan,
Michael S. Kobor,
Ana Paula Santana de Vasconcellos Bittencourt,
Michael J. Meaney,
Carla Dalmaz,
Patrícia Pelufo Silveira

Affiliations

Randriely Merscher Sobreira de Lima: Department of Psychiatry, Faculty of Medicine, McGill University
Barbara Barth: Integrated Program in Neuroscience (IPN), McGill University
Danusa Mar Arcego: Department of Psychiatry, Faculty of Medicine, McGill University
Euclides José de Mendonça Filho: Department of Psychiatry, Faculty of Medicine, McGill University
Sachin Patel: Ludmer Centre for Neuroinformatics and Mental Health, Douglas Research Centre, McGill University
Zihan Wang: Ludmer Centre for Neuroinformatics and Mental Health, Douglas Research Centre, McGill University
Irina Pokhvisneva: Ludmer Centre for Neuroinformatics and Mental Health, Douglas Research Centre, McGill University
Carine Parent: Ludmer Centre for Neuroinformatics and Mental Health, Douglas Research Centre, McGill University
Robert D. Levitan: Department of Psychiatry, University of Toronto and Centre for Addiction and Mental Health
Michael S. Kobor: Centre for Molecular Medicine and Therapeutics, BC Children’s Hospital Research Institute, Department of Medical Genetics, The University of British Columbia
Ana Paula Santana de Vasconcellos Bittencourt: Departamento de Ciências Fisiológicas, Universidade Federal do Espírito Santo
Michael J. Meaney: Department of Psychiatry, Faculty of Medicine, McGill University
Carla Dalmaz: Programa de Pós-Graduação em Neurociências, Instituto de Ciências Básicas da Saúde (ICBS), Universidade Federal do Rio Grande do Sul
Patrícia Pelufo Silveira: Department of Psychiatry, Faculty of Medicine, McGill University

DOI: https://doi.org/10.1038/s42003-022-03992-8
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 10

Abstract

Read online

An expression-based polygenic risk score analysis of leptin receptor (LepR) genes suggests that LepR-specific genes co-expressed in the prefrontal cortex interact with exposure to postnatal adversity, potentially modulating eating behavior in children.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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