EGCG modulates PKD1 and ferroptosis to promote recovery in ST rats

Wang Jianjun; Chen Ying; Chen Long; Duan Yanzhi; Kuang Xuejun; Peng Zhao; Li Conghui; Li Yuanhao; Xiao Yang; Jin Hao; Tan Quandan; Zhang Shaofeng; Zhu Bopei; Tang Yinjuan

doi:10.1515/tnsci-2020-0119

Translational Neuroscience (May 2020)

EGCG modulates PKD1 and ferroptosis to promote recovery in ST rats

Wang Jianjun,
Chen Ying,
Chen Long,
Duan Yanzhi,
Kuang Xuejun,
Peng Zhao,
Li Conghui,
Li Yuanhao,
Xiao Yang,
Jin Hao,
Tan Quandan,
Zhang Shaofeng,
Zhu Bopei,
Tang Yinjuan

Affiliations

Wang Jianjun: Affiliated Hospital, Xiangnan University, Chenzhou 423000, Hunan Province, China
Chen Ying: Jilong Union School of Hengnan County, Hengyang 421000, Hunan Province, China
Chen Long: Department of Clinical, Xiangnan University, Chenzhou 423000, Hunan Province, China
Duan Yanzhi: Department of Clinical, Xiangnan University, Chenzhou 423000, Hunan Province, China
Kuang Xuejun: Affiliated Hospital, Xiangnan University, Chenzhou 423000, Hunan Province, China
Peng Zhao: Affiliated Hospital, Xiangnan University, Chenzhou 423000, Hunan Province, China
Li Conghui: Affiliated Hospital, Xiangnan University, Chenzhou 423000, Hunan Province, China
Li Yuanhao: Department of Clinical, Xiangnan University, Chenzhou 423000, Hunan Province, China
Xiao Yang: Department of Clinical, Xiangnan University, Chenzhou 423000, Hunan Province, China
Jin Hao: Department of Clinical, Xiangnan University, Chenzhou 423000, Hunan Province, China
Tan Quandan: Department of Clinical, Xiangnan University, Chenzhou 423000, Hunan Province, China
Zhang Shaofeng: Department of Clinical, Xiangnan University, Chenzhou 423000, Hunan Province, China
Zhu Bopei: Department of Clinical, Xiangnan University, Chenzhou 423000, Hunan Province, China
Tang Yinjuan: Department of Basic Medical Sciences, Xiangnan University, Chenzhou 423000, Hunan Province, China

DOI: https://doi.org/10.1515/tnsci-2020-0119
Journal volume & issue: Vol. 11, no. 1
pp. 173 – 181

Abstract

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Spinal cord injury (SCI) causes devastating loss of function and neuronal death without effective treatment. (−)-Epigallocatechin-3-gallate (EGCG) has antioxidant properties and plays an essential role in the nervous system. However, the underlying mechanism by which EGCG promotes neuronal survival and functional recovery in complete spinal cord transection (ST) remains unclear.

Published in Translational Neuroscience

ISSN: 2081-6936 (Online)
Publisher: De Gruyter
Country of publisher: Poland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.degruyter.com/view/j/tnsci

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