Food Supplements for Skin Health: In Vitro Efficacy of a Combination of <i>Rhodiola rosea</i>, <i>Tribulus terrestris</i>, <i>Moringa oleifera</i> and <i>Undaria pinnatifida</i> on UV-Induced Damage

Abstract

An increasing number of people seek treatment for aging-related conditions. Plant-derived nutraceuticals are currently of great interest in the setting of dermo-cosmetic studies for their preventive role in photoaging. We conducted an in vitro study on the possible preventive properties against photoaging of a commercially available product (Venerinase®). A mixture of Rhodiola rosea, Tribulus terrestris, Moringa oleifera, Undaria pinnatifida, folic acid and vitamin B12 (Venerinase®) was tested for its potential anti-aging effects on the skin in vitro. Conventional histology, immunofluorescence and real time PCR were employed in the research protocol. The tested product was proven to prevent UV-induced morphological changes both in keratinocytes and fibroblasts. Moreover, senescence-related and proinflammatory pathways commonly triggered by UV exposure were demonstrated to be inhibited by Venerinase® pretreatment. Our results support the potential clinical benefits of oral supplements for the treatment and/or prevention of cutaneous photodamage.

Keywords

• nutraceuticals
• oral supplements
• <i>Rhodiola</i>
• <i>Tribulus</i>
• <i>Moringa</i>
• skin aging