Nature Communications (Mar 2021)

Combination therapy protects macaques against advanced Marburg virus disease

  • Robert W. Cross,
  • Zachary A. Bornholdt,
  • Abhishek N. Prasad,
  • Viktoriya Borisevich,
  • Krystle N. Agans,
  • Daniel J. Deer,
  • Dafna M. Abelson,
  • Do H. Kim,
  • William S. Shestowsky,
  • Lioudmila A. Campbell,
  • Elaine Bunyan,
  • Joan B. Geisbert,
  • Karla A. Fenton,
  • Larry Zeitlin,
  • Danielle P. Porter,
  • Thomas W. Geisbert

DOI
https://doi.org/10.1038/s41467-021-22132-0
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 10

Abstract

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Extending the therapeutic window for acute viral infections could save lives. Here, the authors show that combination treatment with a human monoclonal antibody and remdesivir initiated at 6 days post infection with Marburg virus provides 80% protection in non-human primates.