Grignard Reaction: An ‘Old-Yet-Gold’ synthetic gadget toward the synthesis of natural Products: A review

Abstract

Natural product synthesis is an important area of chemical study having various prospects for medicinal, industrial, and agricultural industry. Grignard reaction was developed as a flexible and necessary tool for the production of complex organic compounds in synthetic procedures. Additionally, the synthetic flexibility of the Grignard reaction facilitates its usage in the construction of more complicated ring frameworks and stereoselective transformations. It has been substantially applied in natural product synthesis, demonstrating its effectiveness in the generation of crucial C-C, C-X bonds and the development of intricate molecular structures. Use of Grignard reaction has been significantly studied towards the synthesis of biologically active natural products such as terpenoids, polyketides, alkaloids and amino acids. This review outlines the numerous instances where Grignard reagents have been exploited in the synthesis of notable natural products since past two years.