Nature Communications (Jun 2017)
Disruption of the C/EBPα—miR-182 balance impairs granulocytic differentiation
- Alexander Arthur Wurm,
- Polina Zjablovskaja,
- Miroslava Kardosova,
- Dennis Gerloff,
- Daniela Bräuer-Hartmann,
- Christiane Katzerke,
- Jens-Uwe Hartmann,
- Touati Benoukraf,
- Stephan Fricke,
- Nadja Hilger,
- Anne-Marie Müller,
- Marius Bill,
- Sebastian Schwind,
- Daniel G. Tenen,
- Dietger Niederwieser,
- Meritxell Alberich-Jorda,
- Gerhard Behre
Affiliations
- Alexander Arthur Wurm
- Division of Hematology and Oncology, Leipzig University Hospital
- Polina Zjablovskaja
- Institute of Molecular Genetics, Academy of Sciences of the Czech Republic
- Miroslava Kardosova
- Institute of Molecular Genetics, Academy of Sciences of the Czech Republic
- Dennis Gerloff
- Division of Hematology and Oncology, Leipzig University Hospital
- Daniela Bräuer-Hartmann
- Division of Hematology and Oncology, Leipzig University Hospital
- Christiane Katzerke
- Division of Hematology and Oncology, Leipzig University Hospital
- Jens-Uwe Hartmann
- Division of Hematology and Oncology, Leipzig University Hospital
- Touati Benoukraf
- Cancer Science Institute, National University of Singapore
- Stephan Fricke
- Fraunhofer Institute for Cell Therapy and Immunology
- Nadja Hilger
- Fraunhofer Institute for Cell Therapy and Immunology
- Anne-Marie Müller
- Fraunhofer Institute for Cell Therapy and Immunology
- Marius Bill
- Division of Hematology and Oncology, Leipzig University Hospital
- Sebastian Schwind
- Division of Hematology and Oncology, Leipzig University Hospital
- Daniel G. Tenen
- Cancer Science Institute, National University of Singapore
- Dietger Niederwieser
- Division of Hematology and Oncology, Leipzig University Hospital
- Meritxell Alberich-Jorda
- Institute of Molecular Genetics, Academy of Sciences of the Czech Republic
- Gerhard Behre
- Division of Hematology and Oncology, Leipzig University Hospital
- DOI
- https://doi.org/10.1038/s41467-017-00032-6
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 16
Abstract
C/EBPα is a critical transcription factor involved in myelopoiesis and its inactivation is associated with acute myeloid leukemia (AML). Here the authors show a negative feedback loop between C/EBPα and miR-182 and identify this miRNA as a marker of high-risk AML.
