Effects of Modified Atkins Diet on Neurocognitive Function in Refractory Epilepsy

Abstract

Background: Diet therapy is an effective intervention to manage a wide range of seizures and has a wide range of acceptance. This anti-epileptic effect of the ketogenic diet and fasting has been linked with increased ketone levels and may lead to hypoproteinemia or growth issues. The modified Atkin diet is safe and can be taken without fluid or caloric restriction. Furthermore, the patient can use unlimited protein and fat. OBJECTIVE: The study finds out the effects of the modified Atkins diet on fatigue and cognitive functional status in refractory epilepsy. MATERIALS AND METHODS: Twenty-seven subjects (17 males, 10 females) suffering from refractory epilepsy were recruited. The mean age range was 09–15 years. The modified Atkins diet prescribed by diet specialists was introduced. The Visual Analog Scale was used for measuring fatigue levels, and the Quality of Life in Childhood Epilepsy was used to examine the effects on life quality in epileptic patients after 16 weeks. Results: The subject’s mean age was 11.7 ± 2.02 years. They had epilepsy for about 7.8 ± 3.1 years. The seizer frequency was about 2–5 days per week. The muscle fatigue level, seizer frequency, and quality of life were improved after 16 weeks (<0.05). Conclusion: The modified Atkins diet exhibits some encouraging results in refractory epilepsy patients.

Keywords

• ketogenic diet
• modified atkins diet
• quality of life
• refractory epilepsy