Comprehensive functional analysis of the tousled-like kinase 2 frequently amplified in aggressive luminal breast cancers

Abstract

Luminal B oestrogen receptor positive breast cancers are generally aggressive tumors with poor outcomes. Here, the authors show that the kinase TLK2 is amplified and overexpressed in these tumors and correlates with reduced survival, TLK2 inhibition induces apoptosis in vitroand improves survival in mice.