Chimica Techno Acta (Dec 2022)

Synthesis, intramolecular cyclization and anti-inflammatory activity of substituted 2-(2-(Furan-2-carbonyl)hydrazono)-4-oxobutanoic Acids

  • Sergei N. Igidov,
  • Dmitriy V. Lipin,
  • Aleksey Yu. Turyshev,
  • Svetlana V. Chashchina,
  • Daria A. Shipilovskikh,
  • Ol’ga V. Zvereva,
  • Ksenia A. Mitusova,
  • Pavel S. Silaichev,
  • Nazim M. Igidov

DOI
https://doi.org/10.15826/chimtech.2023.10.1.02
Journal volume & issue
Vol. 10, no. 1

Abstract

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A method was proposed for the synthesis of substituted 2-(2-(furan-2-carbonyl)hydrazono)-4-oxobutanoic acids by the reaction of substituted 2,4-dioxobut-2-enoic acids with furan-2-carbohydrazide. It was found that substituted 2-(2-(furan-2-carbonyl)hydrazono)-4-oxobutanoic acids undergo intramolecular cyclization in the presence of propionic anhydride to form the corresponding N'-(2-oxofuran-3(2H)-ylidene)furan-2-carbohydrazides. The anti-inflammatory activity of the obtained compounds was studied. It was found that the obtained compounds have pronounced anti-inflammatory activity.

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