Centrosome dysfunction associated with somatic expression of the synaptonemal complex protein TEX12

Sumit Sandhu; Ieng F. Sou; Jill E. Hunter; Lucy Salmon; Caroline L. Wilson; Neil D. Perkins; Neil Hunter; Owen R. Davies; Urszula L. McClurg

doi:10.1038/s42003-021-02887-4

Communications Biology (Dec 2021)

Centrosome dysfunction associated with somatic expression of the synaptonemal complex protein TEX12

Sumit Sandhu,
Ieng F. Sou,
Jill E. Hunter,
Lucy Salmon,
Caroline L. Wilson,
Neil D. Perkins,
Neil Hunter,
Owen R. Davies,
Urszula L. McClurg

Affiliations

Sumit Sandhu: Howard Hughes Medical Institute, Department of Microbiology and Molecular Genetics, University of California
Ieng F. Sou: Institute of Systems, Molecular and Integrative Biology, University of Liverpool
Jill E. Hunter: Biosciences Institute, Newcastle University
Lucy Salmon: Biosciences Institute, Newcastle University
Caroline L. Wilson: Biosciences Institute, Newcastle University
Neil D. Perkins: Biosciences Institute, Newcastle University
Neil Hunter: Howard Hughes Medical Institute, Department of Microbiology and Molecular Genetics, University of California
Owen R. Davies: Biosciences Institute, Newcastle University
Urszula L. McClurg: Institute of Systems, Molecular and Integrative Biology, University of Liverpool

DOI: https://doi.org/10.1038/s42003-021-02887-4
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 13

Abstract

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Sandhu et al. report that the synaptonemal complex (SC) protein, TEX12, localises to centrosomes independently of the SC during meiosis. They also show that it provokes centrosome amplification in somatic cells, a pathology associated with cancer development.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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