Plasticity of the Influenza Virus H5 HA Protein

Huihui Kong; David F. Burke; Tiago Jose da Silva Lopes; Kosuke Takada; Masaki Imai; Gongxun Zhong; Masato Hatta; Shufang Fan; Shiho Chiba; Derek Smith; Gabriele Neumann; Yoshihiro Kawaoka

doi:10.1128/mBio.03324-20

mBio (Feb 2021)

Plasticity of the Influenza Virus H5 HA Protein

Huihui Kong,
David F. Burke,
Tiago Jose da Silva Lopes,
Kosuke Takada,
Masaki Imai,
Gongxun Zhong,
Masato Hatta,
Shufang Fan,
Shiho Chiba,
Derek Smith,
Gabriele Neumann,
Yoshihiro Kawaoka

Affiliations

Huihui Kong: Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin—Madison, Madison, Wisconsin, USA
David F. Burke: Department of Zoology, University of Cambridge, Cambridge, United Kingdom
Tiago Jose da Silva Lopes: Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin—Madison, Madison, Wisconsin, USA
Kosuke Takada: Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
Masaki Imai: Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
Gongxun Zhong: Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin—Madison, Madison, Wisconsin, USA
Masato Hatta: Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin—Madison, Madison, Wisconsin, USA
Shufang Fan: Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin—Madison, Madison, Wisconsin, USA
Shiho Chiba: Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin—Madison, Madison, Wisconsin, USA
Derek Smith: Department of Zoology, University of Cambridge, Cambridge, United Kingdom
Gabriele Neumann: Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin—Madison, Madison, Wisconsin, USA
Yoshihiro Kawaoka: ORCiD; Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin—Madison, Madison, Wisconsin, USA

DOI: https://doi.org/10.1128/mBio.03324-20
Journal volume & issue: Vol. 12, no. 1

Abstract

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The HA protein of influenza A viruses is the major viral antigen. In this study, we simultaneously introduced mutations at 17 amino acid positions of an H5 HA expected to affect antigenicity. Viruses with ≥13 amino acid changes in HA were viable, and some had altered antigenic properties. H5 HA can therefore accommodate many mutations in regions that affect antigenicity. The substantial plasticity of H5 HA may facilitate the emergence of novel antigenic variants.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

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