Spatio-temporal analysis of prostate tumors in situ suggests pre-existence of treatment-resistant clones

Maja Marklund; Niklas Schultz; Stefanie Friedrich; Emelie Berglund; Firas Tarish; Anna Tanoglidi; Yao Liu; Ludvig Bergenstråhle; Andrew Erickson; Thomas Helleday; Alastair D. Lamb; Erik Sonnhammer; Joakim Lundeberg

doi:10.1038/s41467-022-33069-3

Nature Communications (Sep 2022)

Spatio-temporal analysis of prostate tumors in situ suggests pre-existence of treatment-resistant clones

Maja Marklund,
Niklas Schultz,
Stefanie Friedrich,
Emelie Berglund,
Firas Tarish,
Anna Tanoglidi,
Yao Liu,
Ludvig Bergenstråhle,
Andrew Erickson,
Thomas Helleday,
Alastair D. Lamb,
Erik Sonnhammer,
Joakim Lundeberg

Affiliations

Maja Marklund: Department of Gene Technology, KTH Royal Institute of Technology, Science for Life Laboratory
Niklas Schultz: Division of Translational Medicine & Chemical Biology, Karolinska Institute, Science for Life Laboratory
Stefanie Friedrich: Department of Biochemistry and Biophysics, Stockholm University, Science for Laboratory
Emelie Berglund: Department of Gene Technology, KTH Royal Institute of Technology, Science for Life Laboratory
Firas Tarish: Division of Translational Medicine & Chemical Biology, Karolinska Institute, Science for Life Laboratory
Anna Tanoglidi: Department of Pathology, Evangelismos General Hospital
Yao Liu: Division of Translational Medicine & Chemical Biology, Karolinska Institute, Science for Life Laboratory
Ludvig Bergenstråhle: Department of Gene Technology, KTH Royal Institute of Technology, Science for Life Laboratory
Andrew Erickson: Nuffield Department of Surgical Sciences, University of Oxford
Thomas Helleday: Division of Translational Medicine & Chemical Biology, Karolinska Institute, Science for Life Laboratory
Alastair D. Lamb: Nuffield Department of Surgical Sciences, University of Oxford
Erik Sonnhammer: Department of Biochemistry and Biophysics, Stockholm University, Science for Laboratory
Joakim Lundeberg: Department of Gene Technology, KTH Royal Institute of Technology, Science for Life Laboratory

DOI: https://doi.org/10.1038/s41467-022-33069-3
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 18

Abstract

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Spatial heterogeneity in prostate cancer can contribute to its resistance to androgen deprivation therapy (ADT). Here, the authors analyse prostate cancer samples before and after ADT using Spatial Transcriptomics, and find heterogeneous pre-treatment tumour cell populations and stromal cells that are associated with resistance.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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