Chlamydia psittaci inhibits apoptosis of human neutrophils by activating P2X7 receptor expression

Zhangping He; Chuan Wang; Jianye Wang; Kang Zheng; Nan Ding; Maoying Yu; Weiwei Li; Yuanyuan Tang; Yumeng Li; Jian Xiao; Mingxing Liang; Yimou Wu

International Journal of Medical Microbiology (Dec 2022)

Chlamydia psittaci inhibits apoptosis of human neutrophils by activating P2X7 receptor expression

Zhangping He,
Chuan Wang,
Jianye Wang,
Kang Zheng,
Nan Ding,
Maoying Yu,
Weiwei Li,
Yuanyuan Tang,
Yumeng Li,
Jian Xiao,
Mingxing Liang,
Yimou Wu

Affiliations

Zhangping He: Institute of Pathogenic Biology, Hengyang Medical School, University of South China, Hengyang, Hunan, China; Department of Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, University of South China, Hengyang, Hunan, China
Chuan Wang: Institute of Pathogenic Biology, Hengyang Medical School, University of South China, Hengyang, Hunan, China; Department of Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, University of South China, Hengyang, Hunan, China
Jianye Wang: Institute of Pathogenic Biology, Hengyang Medical School, University of South China, Hengyang, Hunan, China; Department of Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, University of South China, Hengyang, Hunan, China
Kang Zheng: Institute of Pathogenic Biology, Hengyang Medical School, University of South China, Hengyang, Hunan, China; Department of Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, University of South China, Hengyang, Hunan, China
Nan Ding: Institute of Pathogenic Biology, Hengyang Medical School, University of South China, Hengyang, Hunan, China; Department of Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, University of South China, Hengyang, Hunan, China
Maoying Yu: Institute of Pathogenic Biology, Hengyang Medical School, University of South China, Hengyang, Hunan, China; Department of Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, University of South China, Hengyang, Hunan, China
Weiwei Li: Institute of Pathogenic Biology, Hengyang Medical School, University of South China, Hengyang, Hunan, China; Department of Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, University of South China, Hengyang, Hunan, China
Yuanyuan Tang: Institute of Pathogenic Biology, Hengyang Medical School, University of South China, Hengyang, Hunan, China; Department of Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, University of South China, Hengyang, Hunan, China
Yumeng Li: The First Affiliated Hospital, Hengyang Medical School, University of South China, Hunan, China
Jian Xiao: The Affiliated Nanhua Hospital, Department of laboratory medicine, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China
Mingxing Liang: Institute of Pathogenic Biology, Hengyang Medical School, University of South China, Hengyang, Hunan, China; Department of Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, University of South China, Hengyang, Hunan, China
Yimou Wu: Institute of Pathogenic Biology, Hengyang Medical School, University of South China, Hengyang, Hunan, China; Department of Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, University of South China, Hengyang, Hunan, China; Correspondence to: Pathogenic Biology Institute, Hengyang Medical School, University of South China, 28 West Changsheng Road, Hengyang, Hunan 421001, China.

Journal volume & issue: Vol. 312, no. 8
p. 151571

Abstract

Read online

This study tested the hypothesis that Chlamydia psittaci (C. psittaci) survives and multiplies in human neutrophils by activating P2X7, a nonselective cationic channel receptor expressed constitutively on the surface of these cells. Findings illustrated that P2X7 receptor expression was enhanced in C. psittaci-infected neutrophils. C. psittaci was able to inhibite spontaneous apoptosis of neutrophils through mitochondrial-induced ATP release and IL-8 production. Importantly, inhibiting ATP activation of the P2X7 receptor with AZ10606120 promotes apoptosis, while stimulating P2X7 receptor expression with BzATP delayed spontaneous apoptosis of human neutrophils, suggesting that C. psittaci inhibits apoptosis of human neutrophils by activating P2X7 receptor. This study reveals new insights into the survival advantages of the latent persistent state of C. psittaci and the mechanism by which it evades the innate immune response.

Published in International Journal of Medical Microbiology

ISSN: 1438-4221 (Print); 1618-0607 (Online)
Publisher: Elsevier
Country of publisher: Germany
LCC subjects: Science: Microbiology; Medicine: Other systems of medicine
Website: https://www.journals.elsevier.com/international-journal-of-medical-microbiology

About the journal

Abstract

Keywords