Italian Journal of Animal Science (Dec 2020)

Efficacy of silymarin-nanohydrogle complex in attenuation of aflatoxins toxicity in Japanese quails

  • Behrouz Khaleghipour,
  • Heshmatollah Khosravinia,
  • Majid Toghiyani,
  • Arash Azarfar

DOI
https://doi.org/10.1080/1828051X.2020.1743782
Journal volume & issue
Vol. 19, no. 1
pp. 351 – 359

Abstract

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A 2 × 3 factorial experiment was conducted to investigate the effects of silymarin-nanohydrogle (0, 500 free; 500 nano) and a mycotoxin (0; 2.2 mg/kg), silymarin contaminated diet on productive performance and certain serum biochemical parameters using 72 Japanese quail chicks in days 7–35 of age. Six experimental treatments consisting inclusion of 0 or 2.2 mg/kg aflatoxins in a basal diet fed to the birds receiving 0 or 500 mg/L silymarin in two free- or nanohydrogle forms via drinking water. Daily weight gain (DWG) and European production index (EPI) reduced by 6.7% and 13.6% while feed intake (FI) and FCR increased by 3.76% and 12% in the birds fed on the diet containing 2.2 mg/kg aflatoxin, respectively (p < .05). Administration of silymarin-nanohydrogle through drinking water improved FI and DWG by 3.7% and 8.1%, respectively (p < .05). Mean serum alkaline phosphatase (ALP) activity elevated by 26.1% and serum concentration of total protein (TP), glucose (GLU) and high density lipoproteins (HDL) declined by 14.4%, 6.1% and 27.1% in the birds fed on the aflatoxin-contaminated diet, respectively (p < .05). Mean serum concentration of BUN (86.4%) and GLU (12.0%) increased and Ca (10.3%) decreased in birds receiving 500 mg/kg silymarin-nanohydrogle (p < .05). The birds receiving silymarin-nanohydrogle in drinking water showed lesser liver and spleen percentage (p < .05). It was concluded that inclusion of 500 mg/kg silymarin-nanohydrogle in drinking water could significantly compensate the impaired growth performance and alter hepatic function in Japanese quails fed on a diet contaminating 2.2 mg aflatoxins.Highlights Feeding diets contaminated with 2.2 mg aflatoxins/kg suppressed growth performance and impaired hepatic function in Japanese quails. Inclusion of 500 mg/kg silymarin-nanohydrogle in drinking water alleviated the adverse impact of aflatoxins on broilers’ performance and partially improved liver function. Greater levels of silymarin-nanohydrogle may relive the aflatoxin-caused intimidating alterations in liver and blood parameters in Japanese quails.

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