Nature Communications (Jan 2023)

Brucella effectors NyxA and NyxB target SENP3 to modulate the subcellular localisation of nucleolar proteins

  • Arthur Louche,
  • Amandine Blanco,
  • Thais Lourdes Santos Lacerda,
  • Lison Cancade-Veyre,
  • Claire Lionnet,
  • Célia Bergé,
  • Monica Rolando,
  • Frédérique Lembo,
  • Jean-Paul Borg,
  • Carmen Buchrieser,
  • Masami Nagahama,
  • Francine C. A. Gérard,
  • Jean-Pierre Gorvel,
  • Virginie Gueguen-Chaignon,
  • Laurent Terradot,
  • Suzana P. Salcedo

DOI
https://doi.org/10.1038/s41467-022-35763-8
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 18

Abstract

Read online

The bacterium Brucella abortus is an intracellular pathogen that modulates autophagy in host cells. Here, the authors identify two B. abortus effectors that interact with host protease SENP3, thus promoting cytoplasmic accumulation of nucleolar proteins associated with ribosomal biogenesis and facilitating intracellular replication of the pathogen