Nature Communications (Oct 2022)
Modeling human telencephalic development and autism-associated SHANK3 deficiency using organoids generated from single neural rosettes
- Yueqi Wang,
- Simone Chiola,
- Guang Yang,
- Chad Russell,
- Celeste J. Armstrong,
- Yuanyuan Wu,
- Jay Spampanato,
- Paisley Tarboton,
- H. M. Arif Ullah,
- Nicolas U. Edgar,
- Amelia N. Chang,
- David A. Harmin,
- Vittoria Dickinson Bocchi,
- Elena Vezzoli,
- Dario Besusso,
- Jun Cui,
- Elena Cattaneo,
- Jan Kubanek,
- Aleksandr Shcheglovitov
Affiliations
- Yueqi Wang
- Department of Neurobiology, University of Utah
- Simone Chiola
- Department of Neurobiology, University of Utah
- Guang Yang
- Department of Neurobiology, University of Utah
- Chad Russell
- Department of Biomedical Engineering, University of Utah
- Celeste J. Armstrong
- Department of Neurobiology, University of Utah
- Yuanyuan Wu
- Department of Neurobiology, University of Utah
- Jay Spampanato
- Department of Neurosurgery, University of Utah
- Paisley Tarboton
- Department of Biomedical Engineering, University of Utah
- H. M. Arif Ullah
- Department of Neurobiology, University of Utah
- Nicolas U. Edgar
- Department of Neurobiology, University of Utah
- Amelia N. Chang
- Department of Neurobiology, Harvard Medical School
- David A. Harmin
- Department of Neurobiology, Harvard Medical School
- Vittoria Dickinson Bocchi
- Department of Biosciences, University of Milan
- Elena Vezzoli
- Department of Biosciences, University of Milan
- Dario Besusso
- Department of Biosciences, University of Milan
- Jun Cui
- Department of Cell Biology and Neurosciences, Montana State University
- Elena Cattaneo
- Department of Biosciences, University of Milan
- Jan Kubanek
- Department of Biomedical Engineering, University of Utah
- Aleksandr Shcheglovitov
- Department of Neurobiology, University of Utah
- DOI
- https://doi.org/10.1038/s41467-022-33364-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 25
Abstract
Our understanding of human brain development in health and disease is limited. The authors generated human brain organoids from stem cell-derived isolated single neural rosettes to study human cortico-striatal development and deficits caused by an autism-associated genetic abnormality in SHANK3.
