Nature Communications (Nov 2017)
Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25
- Stephen W. Scally,
- Brandon McLeod,
- Alexandre Bosch,
- Kazutoyo Miura,
- Qi Liang,
- Sean Carroll,
- Sini Reponen,
- Ngan Nguyen,
- Eldar Giladi,
- Sebastian Rämisch,
- Vidadi Yusibov,
- Allan Bradley,
- Franck Lemiale,
- William R. Schief,
- Daniel Emerling,
- Paul Kellam,
- C. Richter King,
- Jean-Philippe Julien
Affiliations
- Stephen W. Scally
- Program in Molecular Medicine, The Hospital for Sick Children Research Institute
- Brandon McLeod
- Program in Molecular Medicine, The Hospital for Sick Children Research Institute
- Alexandre Bosch
- Program in Molecular Medicine, The Hospital for Sick Children Research Institute
- Kazutoyo Miura
- Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Qi Liang
- Kymab Ltd.
- Sean Carroll
- Atreca
- Sini Reponen
- Atreca
- Ngan Nguyen
- Atreca
- Eldar Giladi
- Atreca
- Sebastian Rämisch
- Department of Immunology and Microbiology, The Scripps Research Institute
- Vidadi Yusibov
- Fraunhofer USA Center for Molecular Biotechnology CMB
- Allan Bradley
- Kymab Ltd.
- Franck Lemiale
- PATH’s Malaria Vaccine Initiative
- William R. Schief
- Department of Immunology and Microbiology, The Scripps Research Institute
- Daniel Emerling
- Atreca
- Paul Kellam
- Kymab Ltd.
- C. Richter King
- PATH’s Malaria Vaccine Initiative
- Jean-Philippe Julien
- Program in Molecular Medicine, The Hospital for Sick Children Research Institute
- DOI
- https://doi.org/10.1038/s41467-017-01924-3
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 11
Abstract
Plasmodium falciparum protein Pfs25 is a promising malaria transmission blocking vaccine antigen. Here, Scally et al. determine the crystal structure of Pfs25 and identify antigenic sites that are recognized by transmission-blocking antibodies elicited in human immunoglobulin loci transgenic mice.
