Nature Communications (Sep 2021)
Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer
- Vrutant V. Shah,
- Aundrietta D. Duncan,
- Shiming Jiang,
- Sabrina A. Stratton,
- Kendra L. Allton,
- Clinton Yam,
- Abhinav Jain,
- Patrick M. Krause,
- Yue Lu,
- Shirong Cai,
- Yizheng Tu,
- Xinhui Zhou,
- Xiaomei Zhang,
- Yan Jiang,
- Christopher L. Carroll,
- Zhijun Kang,
- Bin Liu,
- Jianjun Shen,
- Mihai Gagea,
- Sebastian M. Manu,
- Lei Huo,
- Michael Gilcrease,
- Reid T. Powell,
- Lei Guo,
- Clifford Stephan,
- Peter J. Davies,
- Jan Parker-Thornburg,
- Guillermina Lozano,
- Richard R. Behringer,
- Helen Piwnica-Worms,
- Jeffrey T. Chang,
- Stacy L. Moulder,
- Michelle Craig Barton
Affiliations
- Vrutant V. Shah
- Department of Genetics, The University of Texas MD Anderson Cancer Center
- Aundrietta D. Duncan
- The University of Texas MD Anderson Cancer Center
- Shiming Jiang
- The University of Texas MD Anderson Cancer Center
- Sabrina A. Stratton
- The University of Texas MD Anderson Cancer Center
- Kendra L. Allton
- The University of Texas MD Anderson Cancer Center
- Clinton Yam
- The University of Texas MD Anderson Cancer Center
- Abhinav Jain
- The University of Texas MD Anderson Cancer Center
- Patrick M. Krause
- Department of Genetics, The University of Texas MD Anderson Cancer Center
- Yue Lu
- The University of Texas MD Anderson Cancer Center
- Shirong Cai
- The University of Texas MD Anderson Cancer Center
- Yizheng Tu
- The University of Texas MD Anderson Cancer Center
- Xinhui Zhou
- The University of Texas MD Anderson Cancer Center
- Xiaomei Zhang
- The University of Texas MD Anderson Cancer Center
- Yan Jiang
- The University of Texas MD Anderson Cancer Center
- Christopher L. Carroll
- The University of Texas MD Anderson Cancer Center
- Zhijun Kang
- The University of Texas MD Anderson Cancer Center
- Bin Liu
- The University of Texas MD Anderson Cancer Center
- Jianjun Shen
- The University of Texas MD Anderson Cancer Center
- Mihai Gagea
- The University of Texas MD Anderson Cancer Center
- Sebastian M. Manu
- The University of Texas MD Anderson Cancer Center
- Lei Huo
- The University of Texas MD Anderson Cancer Center
- Michael Gilcrease
- The University of Texas MD Anderson Cancer Center
- Reid T. Powell
- Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M College of Medicine
- Lei Guo
- Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M College of Medicine
- Clifford Stephan
- Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M College of Medicine
- Peter J. Davies
- Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M College of Medicine
- Jan Parker-Thornburg
- Department of Genetics, The University of Texas MD Anderson Cancer Center
- Guillermina Lozano
- Department of Genetics, The University of Texas MD Anderson Cancer Center
- Richard R. Behringer
- Department of Genetics, The University of Texas MD Anderson Cancer Center
- Helen Piwnica-Worms
- The University of Texas MD Anderson Cancer Center
- Jeffrey T. Chang
- University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, University of Texas
- Stacy L. Moulder
- The University of Texas MD Anderson Cancer Center
- Michelle Craig Barton
- The University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/s41467-021-25650-z
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Human metaplastic breast cancers (MpBC) are a rare, aggressive subclass of triple-negative breast cancers. Here, the authors show over-expression of histone reader TRIM24 is sufficient to generate tumors with a molecular signature of metabolic dysfunction and EMT in a mouse model of human MpBC.
