Associations Between Thyroid Volume and Physical Growth in Pubertal Girls: Thyroid Volume Indexes Need to Be Applied to Thyroid Volume Assessments

Yingying Wang; Yingying Wang; Xiaolian Dong; Chaowei Fu; Chaowei Fu; Meifang Su; Feng Jiang; Feng Jiang; Dongli Xu; Rui Li; Rui Li; Peixin Huang; Na Wang; Na Wang; Yue Chen; Qingwu Jiang; Qingwu Jiang

doi:10.3389/fendo.2021.662543

Frontiers in Endocrinology (May 2021)

Associations Between Thyroid Volume and Physical Growth in Pubertal Girls: Thyroid Volume Indexes Need to Be Applied to Thyroid Volume Assessments

Yingying Wang,
Yingying Wang,
Xiaolian Dong,
Chaowei Fu,
Chaowei Fu,
Meifang Su,
Feng Jiang,
Feng Jiang,
Dongli Xu,
Rui Li,
Rui Li,
Peixin Huang,
Na Wang,
Na Wang,
Yue Chen,
Qingwu Jiang,
Qingwu Jiang

Affiliations

Yingying Wang: Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China
Yingying Wang: Key Laboratory of Public Health Safety of Ministry of Education, School of Public Health, Fudan University, Shanghai, China
Xiaolian Dong: Department of Chronic Disease Control and Prevention, Deqing County Center for Disease Control and Prevention, Huzhou, China
Chaowei Fu: Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China
Chaowei Fu: Key Laboratory of Public Health Safety of Ministry of Education, School of Public Health, Fudan University, Shanghai, China
Meifang Su: Department of Chronic Disease Control and Prevention, Yuhuan City Center for Disease Control and Prevention, Taizhou, China
Feng Jiang: Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China
Feng Jiang: Key Laboratory of Public Health Safety of Ministry of Education, School of Public Health, Fudan University, Shanghai, China
Dongli Xu: Department of Chronic Disease Control and Prevention, Minhang District Center for Disease Control and Prevention, Shanghai, China
Rui Li: Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China
Rui Li: Key Laboratory of Public Health Safety of Ministry of Education, School of Public Health, Fudan University, Shanghai, China
Peixin Huang: Department of Chronic Disease Control and Prevention, Haimen City Center for Disease Control and Prevention, Nantong, China
Na Wang: Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China
Na Wang: Key Laboratory of Public Health Safety of Ministry of Education, School of Public Health, Fudan University, Shanghai, China
Yue Chen: School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada
Qingwu Jiang: Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China
Qingwu Jiang: Key Laboratory of Public Health Safety of Ministry of Education, School of Public Health, Fudan University, Shanghai, China

DOI: https://doi.org/10.3389/fendo.2021.662543
Journal volume & issue: Vol. 12

Abstract

Read online

BackgroundThyroid volume (Tvol) is associated with many factors, but the current reference values for Tvol in children with sufficient iodine intake are inappropriate and need to be updated. Moderate changes in thyroid morphology and accentuated increases in body fat percentage occur during puberty as an adaption of the body and sexual development occurs. This study aimed to evaluate the influences of physical growth on Tvol and propose an easily applicable method for conducting Tvol assessments in pubertal girls with sufficient iodine intake.MethodsA cohort study was conducted on 481 pubertal girls in East China from 2017 to 2019. B-ultrasound was used to assess Tvol. Multiple linear regression models were used to estimate the associations of Tvol enlargement (dTvol) with changes in height (dH), weight (dW), waist circumference (dW), body mass index (dBMI), and body surface area (dBSA). Thyroid volume indexes (TVIs), including height thyroid volume index (HVI), weight and height thyroid volume index (WHVI), body mass index thyroid index (BMIV), and body surface area thyroid index (BSAV), were calculated to explore an appropriate method for Tvol assessments by Spearman correlation analyses.ResultsTvol, height, weight, BMI, and BSA increased significantly from baseline to follow-up (P<0.001). The associations between dTvol and physical growth were only observed in the 13 to 14-year-old group. dH, dW,dBMI, and dBSA were positively related to dTvol, with the maximum β of 5.74 (95%CI: 2.54 to 8.94) on dBSA, while dWC was negatively related to dTvol (β= -0.05, 95%CI: -0.08 to -0.03). Both dHVI and dBSAV were not associated with dH, dW, dBMI, or dBSA in both age groups (P>0.05).ConclusionsThyroid volume was associated with physical growth in pubertal girls in East China, both age and anthropometric measurements must be comprehensively considered to establish the reference values for Tvol. HVI, and BSAV may be better indicators for Tvol assessments in pubertal girls.

Published in Frontiers in Endocrinology

ISSN: 1664-2392 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology
Website: https://www.frontiersin.org/journals/endocrinology

About the journal

Abstract

Keywords