Nature Communications (Oct 2019)
Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis
- C. S. Gallagher,
- N. Mäkinen,
- H. R. Harris,
- N. Rahmioglu,
- O. Uimari,
- J. P. Cook,
- N. Shigesi,
- T. Ferreira,
- D. R. Velez-Edwards,
- T. L. Edwards,
- S. Mortlock,
- Z. Ruhioglu,
- F. Day,
- C. M. Becker,
- V. Karhunen,
- H. Martikainen,
- M.-R. Järvelin,
- R. M. Cantor,
- P. M. Ridker,
- K. L. Terry,
- J. E. Buring,
- S. D. Gordon,
- S. E. Medland,
- G. W. Montgomery,
- D. R. Nyholt,
- D. A. Hinds,
- J. Y. Tung,
- the 23andMe Research Team,
- J. R. B. Perry,
- P. A. Lind,
- J. N. Painter,
- N. G. Martin,
- A. P. Morris,
- D. I. Chasman,
- S. A. Missmer,
- K. T. Zondervan,
- C. C. Morton
Affiliations
- C. S. Gallagher
- Department of Genetics, Harvard Medical School
- N. Mäkinen
- Department of Obstetrics and Gynecology, Brigham and Women’s Hospital, Harvard Medical School
- H. R. Harris
- Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center
- N. Rahmioglu
- Wellcome Centre for Human Genetics, University of Oxford
- O. Uimari
- Endometriosis CaRe Centre, Nuffield Department of Women’s and Reproductive Health, University of Oxford, John Radcliffe Hospital
- J. P. Cook
- Department of Biostatistics, University of Liverpool
- N. Shigesi
- Endometriosis CaRe Centre, Nuffield Department of Women’s and Reproductive Health, University of Oxford, John Radcliffe Hospital
- T. Ferreira
- Wellcome Centre for Human Genetics, University of Oxford
- D. R. Velez-Edwards
- Vanderbilt Genetics Institute, Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center
- T. L. Edwards
- Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center
- S. Mortlock
- Institute for Molecular Bioscience, University of Queensland
- Z. Ruhioglu
- Department of Obstetrics and Gynecology, Brigham and Women’s Hospital, Harvard Medical School
- F. Day
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus
- C. M. Becker
- Endometriosis CaRe Centre, Nuffield Department of Women’s and Reproductive Health, University of Oxford, John Radcliffe Hospital
- V. Karhunen
- Center for Life Course Health Research, Faculty of Medicine, University of Oulu
- H. Martikainen
- Department of Obstetrics and Gynecology, Oulu University Hospital and PEDEGO Research Unit & Medical Research Center Oulu, University of Oulu and Oulu University Hospital
- M.-R. Järvelin
- Center for Life Course Health Research, Faculty of Medicine, University of Oulu
- R. M. Cantor
- Department of Human Genetics, David Geffen School of Medicine, University of California at Los Angeles
- P. M. Ridker
- Division of Preventative Medicine, Brigham and Women’s Hospital, Harvard Medical School
- K. L. Terry
- Obstetrics and Gynecology Epidemiology Center, Brigham and Women’s Hospital and Harvard Medical School
- J. E. Buring
- Division of Preventative Medicine, Brigham and Women’s Hospital, Harvard Medical School
- S. D. Gordon
- Genetic Epidemiology, QIMR Berghofer Medical Research Institute
- S. E. Medland
- Psychiatric Genetics, QIMR Berghofer Medical Research Institute
- G. W. Montgomery
- Institute for Molecular Bioscience, University of Queensland
- D. R. Nyholt
- Genetic Epidemiology, QIMR Berghofer Medical Research Institute
- D. A. Hinds
- 23andMe
- J. Y. Tung
- 23andMe
- the 23andMe Research Team
- J. R. B. Perry
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus
- P. A. Lind
- Psychiatric Genetics, QIMR Berghofer Medical Research Institute
- J. N. Painter
- Psychiatric Genetics, QIMR Berghofer Medical Research Institute
- N. G. Martin
- Genetic Epidemiology, QIMR Berghofer Medical Research Institute
- A. P. Morris
- Wellcome Centre for Human Genetics, University of Oxford
- D. I. Chasman
- Division of Preventative Medicine, Brigham and Women’s Hospital, Harvard Medical School
- S. A. Missmer
- Department of Epidemiology, Harvard T.H. Chan School of Public Health
- K. T. Zondervan
- Wellcome Centre for Human Genetics, University of Oxford
- C. C. Morton
- Department of Obstetrics and Gynecology, Brigham and Women’s Hospital, Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-019-12536-4
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 11
Abstract
Uterine leiomyomata (UL) or fibroids are neoplasms of the uterine smooth muscle associated with heavy menstrual bleeding and other female reproductive tract morbidity. Here, the authors identify eight previously undescribed genetic loci for UL and further look into genetic overlap with heavy menstrual bleeding and endometriosis.
