Nature Communications (Aug 2022)

DAXX-ATRX regulation of p53 chromatin binding and DNA damage response

  • Nitish Gulve,
  • Chenhe Su,
  • Zhong Deng,
  • Samantha S. Soldan,
  • Olga Vladimirova,
  • Jayamanna Wickramasinghe,
  • Hongwu Zheng,
  • Andrew V. Kossenkov,
  • Paul. M. Lieberman

DOI
https://doi.org/10.1038/s41467-022-32680-8
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 14

Abstract

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The tumor suppressor proteins DAXX and ATRX are frequently mutated in cancers with alternative lengthening of telomeres (ALT). This study shows that DAXX-ATRX regulates p53 chromatin accessibility and DNA damage response and that disruption of this pathway is critical for ALT cell survival.