Direct correlation between the scores of PANSS/AIMS scales and some oxidative stress markers in treated schizophrenic patients

Abstract

Oxidative stress is increasingly viewed as potentially important in the pathophysiology of schizophrenia, although most results regarding this subject are contradictory. We previously demonstrated an increased oxidative stress status in schizophrenic patients, regardless of their treatment. In this paper, we were interested in whether there is a correlation between the specific activities of the most important antioxidant enzymes (superoxide dismutase and glutathione peroxidase) and a lipid peroxidation marker (malondialdehyde) and the scores of PANSS/AIMS scales. A direct significant correlation was observed between oxidative stress markers and the aforementioned scales. Our results provide additional evidence regarding the implications of oxidative stress in patients with schizophrenia.

Keywords

• schizophrenia
• oxidative stress
• Positive and Negative Syndrome Scale (PANSS)
• Abnormal Involuntary Movement Scale (AIMS)