Methods of Detecting the Reduction of Myocardial Contractility in Patients with Oncohematological Profile in the Course of Polychemotherapy

Abstract

The article is devoted to the modern representation of methods of diagnostics of subclinical myocardial contractile dysfunction in oncohematological patients in the course of chemotherapeutic treatment. Taking into account that the possibilities of standard echocardiographic examination not always allow to identify the subclinical dysfunction of the left ventricle (LV) myocardium, it is necessary to use more sensitive diagnostic strategies for the monitoring of myocardial function. The aim of this literature review is to present problems and prospects for detecting early, subclinical changes in the contractility of the LV myocardium in oncohematological patients who have undergone chemotherapeutic treatment, and to assess their significance as predictors of late chemotherapeutic cardiotoxicity. Echocardiography to assess global longitudinal strain (GLS), stress echocardiography (SE) with determination of the contractile reserve (CR) have a predictive role in the diagnosis of changes in myocardial contractility at early stages and the use of these methods in the examination of oncohematological patients will improve their quality of life and increase its duration.

Keywords

• echocardiography
• ejection fraction
• global longitudinal strain
• stress echocardiography
• left ventricular contractile reserve