Nature Communications (Sep 2022)
Small soluble α-synuclein aggregates are the toxic species in Parkinson’s disease
- Derya Emin,
- Yu P. Zhang,
- Evgeniia Lobanova,
- Alyssa Miller,
- Xuecong Li,
- Zengjie Xia,
- Helen Dakin,
- Dimitrios I. Sideris,
- Jeff Y. L. Lam,
- Rohan T. Ranasinghe,
- Antonina Kouli,
- Yanyan Zhao,
- Suman De,
- Tuomas P. J. Knowles,
- Michele Vendruscolo,
- Francesco S. Ruggeri,
- Franklin I. Aigbirhio,
- Caroline H. Williams-Gray,
- David Klenerman
Affiliations
- Derya Emin
- Yusuf Hamied Department of Chemistry, University of Cambridge
- Yu P. Zhang
- Yusuf Hamied Department of Chemistry, University of Cambridge
- Evgeniia Lobanova
- Yusuf Hamied Department of Chemistry, University of Cambridge
- Alyssa Miller
- Yusuf Hamied Department of Chemistry, University of Cambridge
- Xuecong Li
- Laboratory of Organic Chemistry, Wageningen University and Research
- Zengjie Xia
- Yusuf Hamied Department of Chemistry, University of Cambridge
- Helen Dakin
- Yusuf Hamied Department of Chemistry, University of Cambridge
- Dimitrios I. Sideris
- Yusuf Hamied Department of Chemistry, University of Cambridge
- Jeff Y. L. Lam
- Yusuf Hamied Department of Chemistry, University of Cambridge
- Rohan T. Ranasinghe
- Yusuf Hamied Department of Chemistry, University of Cambridge
- Antonina Kouli
- John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge
- Yanyan Zhao
- Molecular Imaging Chemistry Laboratory, Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge
- Suman De
- Yusuf Hamied Department of Chemistry, University of Cambridge
- Tuomas P. J. Knowles
- Yusuf Hamied Department of Chemistry, University of Cambridge
- Michele Vendruscolo
- Yusuf Hamied Department of Chemistry, University of Cambridge
- Francesco S. Ruggeri
- Yusuf Hamied Department of Chemistry, University of Cambridge
- Franklin I. Aigbirhio
- Molecular Imaging Chemistry Laboratory, Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge
- Caroline H. Williams-Gray
- John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge
- David Klenerman
- Yusuf Hamied Department of Chemistry, University of Cambridge
- DOI
- https://doi.org/10.1038/s41467-022-33252-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
α-synuclein aggregates cause neuronal damage, but their heterogeneity complicates studying their toxic properties. Here, the authors analyze α-synuclein aggregates in vitro and study post-mortem brain samples, providing evidence that small aggregates are the main culprit for neuronal death in Parkinson’s disease.
