Nature Communications (Feb 2020)
Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing
- Michael Sorkin,
- Amanda K. Huber,
- Charles Hwang,
- William F. Carson,
- Rajasree Menon,
- John Li,
- Kaetlin Vasquez,
- Chase Pagani,
- Nicole Patel,
- Shuli Li,
- Noelle D. Visser,
- Yashar Niknafs,
- Shawn Loder,
- Melissa Scola,
- Dylan Nycz,
- Katherine Gallagher,
- Laurie K. McCauley,
- Jiajia Xu,
- Aaron W. James,
- Shailesh Agarwal,
- Stephen Kunkel,
- Yuji Mishina,
- Benjamin Levi
Affiliations
- Michael Sorkin
- Section of Plastic Surgery, Department of Surgery, University of Michigan
- Amanda K. Huber
- Section of Plastic Surgery, Department of Surgery, University of Michigan
- Charles Hwang
- Section of Plastic Surgery, Department of Surgery, University of Michigan
- William F. Carson
- Department of Pathology, University of Michigan
- Rajasree Menon
- Department of Computational Medicine and Bioinformatics, University of Michigan
- John Li
- Section of Plastic Surgery, Department of Surgery, University of Michigan
- Kaetlin Vasquez
- Section of Plastic Surgery, Department of Surgery, University of Michigan
- Chase Pagani
- Section of Plastic Surgery, Department of Surgery, University of Michigan
- Nicole Patel
- Section of Plastic Surgery, Department of Surgery, University of Michigan
- Shuli Li
- Section of Plastic Surgery, Department of Surgery, University of Michigan
- Noelle D. Visser
- Section of Plastic Surgery, Department of Surgery, University of Michigan
- Yashar Niknafs
- Section of Plastic Surgery, Department of Surgery, University of Michigan
- Shawn Loder
- Section of Plastic Surgery, Department of Surgery, University of Michigan
- Melissa Scola
- Department of Pathology, University of Michigan
- Dylan Nycz
- Division of Vascular Surgery, Department of Surgery, University of Michigan
- Katherine Gallagher
- Division of Vascular Surgery, Department of Surgery, University of Michigan
- Laurie K. McCauley
- Department of Periodontics and Oral Medicine, University of Michigan
- Jiajia Xu
- Department of Pathology, Johns Hopkins University
- Aaron W. James
- Department of Pathology, Johns Hopkins University
- Shailesh Agarwal
- Section of Plastic Surgery, Department of Surgery, University of Michigan
- Stephen Kunkel
- Department of Pathology, University of Michigan
- Yuji Mishina
- Department of Biologic and Material Sciences, School of Dentistry, University of Michigan
- Benjamin Levi
- Section of Plastic Surgery, Department of Surgery, University of Michigan
- DOI
- https://doi.org/10.1038/s41467-019-14172-4
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
Aberrant tissue repair may result in heterotopic ossification (HO), but how this process is regulated by local inflammatory responses is still unclear. Here the authors show, using a mouse burn/trauma model, that TGFβ-producing monocytes/macrophages at the injury site contribute to HO induction, while CD47 activation helps antagonize this process.
