Nature Communications (Aug 2020)
Warsaw Breakage Syndrome associated DDX11 helicase resolves G-quadruplex structures to support sister chromatid cohesion
- Janne J. M. van Schie,
- Atiq Faramarz,
- Jesper A. Balk,
- Grant S. Stewart,
- Erika Cantelli,
- Anneke B. Oostra,
- Martin A. Rooimans,
- Joanna L. Parish,
- Cynthia de Almeida Estéves,
- Katja Dumic,
- Ingeborg Barisic,
- Karin E. M. Diderich,
- Marjon A. van Slegtenhorst,
- Mohammad Mahtab,
- Francesca M. Pisani,
- Hein te Riele,
- Najim Ameziane,
- Rob M. F. Wolthuis,
- Job de Lange
Affiliations
- Janne J. M. van Schie
- Section of Oncogenetics, Cancer Center Amsterdam and Department of Clinical Genetics, Amsterdam University Medical Centers
- Atiq Faramarz
- Section of Oncogenetics, Cancer Center Amsterdam and Department of Clinical Genetics, Amsterdam University Medical Centers
- Jesper A. Balk
- Section of Oncogenetics, Cancer Center Amsterdam and Department of Clinical Genetics, Amsterdam University Medical Centers
- Grant S. Stewart
- Institute of Cancer and Genomic Sciences, University of Birmingham
- Erika Cantelli
- Netherlands Cancer Institute, Division of Tumor Biology and Immunology
- Anneke B. Oostra
- Section of Oncogenetics, Cancer Center Amsterdam and Department of Clinical Genetics, Amsterdam University Medical Centers
- Martin A. Rooimans
- Section of Oncogenetics, Cancer Center Amsterdam and Department of Clinical Genetics, Amsterdam University Medical Centers
- Joanna L. Parish
- Institute of Cancer and Genomic Sciences, University of Birmingham
- Cynthia de Almeida Estéves
- Departamento de Genetica, Hospital Militar
- Katja Dumic
- Department of Pediatric Endocrinology and Diabetes, University Hospital Centre Zagreb, University of Zagreb Medical School
- Ingeborg Barisic
- Children’s Hospital Zagreb, Center of Excellence for Reproductive and Regenerative Medicine, Medical School University of Zagreb
- Karin E. M. Diderich
- Department of Clinical Genetics, Erasmus Medical Center
- Marjon A. van Slegtenhorst
- Department of Clinical Genetics, Erasmus Medical Center
- Mohammad Mahtab
- Istituto di Biochimica e Biologia Cellulare, Consiglio Nazionale delle Ricerche
- Francesca M. Pisani
- Istituto di Biochimica e Biologia Cellulare, Consiglio Nazionale delle Ricerche
- Hein te Riele
- Netherlands Cancer Institute, Division of Tumor Biology and Immunology
- Najim Ameziane
- Section of Oncogenetics, Cancer Center Amsterdam and Department of Clinical Genetics, Amsterdam University Medical Centers
- Rob M. F. Wolthuis
- Section of Oncogenetics, Cancer Center Amsterdam and Department of Clinical Genetics, Amsterdam University Medical Centers
- Job de Lange
- Section of Oncogenetics, Cancer Center Amsterdam and Department of Clinical Genetics, Amsterdam University Medical Centers
- DOI
- https://doi.org/10.1038/s41467-020-18066-8
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 18
Abstract
WABS patient derived cells display loss of sister chromatid cohesion. Here the authors by analyzing WABS patient derived cells, reveal a role of the DDX11 helicase in resolving G-Quadruplex structures to support sister chromatid cohesion.
