Frontiers in Genetics (Nov 2021)

Current HLA Investigations on SARS-CoV-2 and Perspectives

  • Venceslas Douillard,
  • Erick C. Castelli,
  • Steven J. Mack,
  • Jill A. Hollenbach,
  • Pierre-Antoine Gourraud,
  • Nicolas Vince,
  • Sophie Limou,
  • Sophie Limou,
  • for the Covid-19|HLA & Immunogenetics Consortium and the SNP-HLA Reference Consortium

DOI
https://doi.org/10.3389/fgene.2021.774922
Journal volume & issue
Vol. 12

Abstract

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The rapid, global spread of the SARS-CoV-2 virus during the current pandemic has triggered numerous efforts in clinical and research settings to better understand the host genetics’ interactions and the severity of COVID-19. Due to the established major role played by MHC/HLA polymorphism in infectious disease course and susceptibility, immunologists and geneticists have teamed up to investigate its contribution to the SARS-CoV-2 infection and COVID-19 progression. A major goal of the Covid-19|HLA & Immunogenetics Consortium is to support and unify these efforts. Here, we present a review of HLA immunogenomics studies in the SARS-CoV-2 pandemic and reflect on the role of various HLA data, their limitation and future perspectives.

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