CircRNA: A new class of targets for gastric cancer drug resistance therapy

Ying Zheng; Ying Zheng; Ying Zheng; Zhe Li; Zhe Li; Yao Wang; Yao Wang; Yao Wang; Wanjiao Chen; Yifan Lin; Yifan Lin; Junming Guo; Junming Guo; Junming Guo; Guoliang Ye; Guoliang Ye

doi:10.3389/pore.2023.1611033

Pathology and Oncology Research (Mar 2023)

CircRNA: A new class of targets for gastric cancer drug resistance therapy

Ying Zheng,
Ying Zheng,
Ying Zheng,
Zhe Li,
Zhe Li,
Yao Wang,
Yao Wang,
Yao Wang,
Wanjiao Chen,
Yifan Lin,
Yifan Lin,
Junming Guo,
Junming Guo,
Junming Guo,
Guoliang Ye,
Guoliang Ye

Affiliations

Ying Zheng: Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo, China
Ying Zheng: Department of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo, China
Ying Zheng: Institute of Digestive Diseases of Ningbo University, Ningbo, China
Zhe Li: Department of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo, China
Zhe Li: Institute of Digestive Diseases of Ningbo University, Ningbo, China
Yao Wang: Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo, China
Yao Wang: Department of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo, China
Yao Wang: Institute of Digestive Diseases of Ningbo University, Ningbo, China
Wanjiao Chen: Department of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo, China
Yifan Lin: Department of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo, China
Yifan Lin: Institute of Digestive Diseases of Ningbo University, Ningbo, China
Junming Guo: Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo, China
Junming Guo: Department of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo, China
Junming Guo: Institute of Digestive Diseases of Ningbo University, Ningbo, China
Guoliang Ye: Department of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo, China
Guoliang Ye: Institute of Digestive Diseases of Ningbo University, Ningbo, China

DOI: https://doi.org/10.3389/pore.2023.1611033
Journal volume & issue: Vol. 29

Abstract

Read online

Gastric cancer (GC) is one of the most common malignancies worldwide. Patients with advanced GC need palliative care to ensure survival. This includes the use of chemotherapy agents, such as cisplatin, 5-fluorouracil, oxaliplatin, paclitaxel, and pemetrexed, as well as targeted agents. However, the emergence of drug resistance evidence in poor patient outcomes and poor prognosis is a motivation to determine the specific mechanism of drug resistance. Interestingly, circular RNAs (circRNAs) play an important part in the carcinogenesis and progression of GC and are involved in GC drug resistance. This review systematically summarizes the functions and mechanisms of circRNAs underlying GC drug resistance, especially chemoresistance. It also emphasizes that circRNAs can serve as promising targets for improving drug resistance and therapeutic efficacy.

Published in Pathology and Oncology Research

ISSN: 1532-2807 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens; Medicine: Pathology
Website: https://www.por-journal.com/journals/pathology-and-oncology-research

About the journal

Abstract

Keywords