Effects of Lacosamide in Cerebral Tuberculoma–Induced Nonconvulsive Status Epilepticus: A Case Report

Abstract

Nonconvulsive status epilepticus (NCSE) is characterized by unexplained changes in behavioral and mental status accompanied by a continuous seizure activity seen on electroencephalography. The treatment is similar to that of status epilepticus. Lacosamide is one of the newer antiepileptic drugs that slows down the inactivation of voltage-dependent sodium channels. It has high oral bioavailability and low protein binding, and is primarily metabolized by the liver enzyme CYP2C19. Central nervous system (CNS) tuberculosis may present with signs of parenchymal lesions instead of meningitis. This study aimed to present a case study of a patient who was diagnosed with CNS tuberculosis a year ago with NCSE, which could be not controlled by levetiracetam. However, the use of lacosamide successfully resolved the NCSE condition.

Keywords

• cns tuberculoma
• lacosamide
• nonconvulsive status epilepticus