The Study of Apelin-13 for the Assessment of Endothelial Dysfunction in Prehypertension and Hypertension Patients

Abstract

Background and aim: Hypertension is a leading global burden of deaths, coronary heart diseases, and stroke. Hypertension causes low-grade chronic systemic inflammation associated with endothelial dysfunction and vascular complications. The present study aimed to assess Apelin-13 levels in prehypertension and hypertension patients and find their association with oxidized low-density lipoprotein (LDL) and lipid profile.Material and methods: Sixty prehypertension and 60 hypertension with the age group of 35 to 50 years were selected, and 60 healthy age-matched subjects were selected as controls. Beckman Colter's fully automated analyzer carried out serum apelin-13 and oxidized LDL estimated by enzyme-linked immunosorbent assay (ELISA) and other routine investigations.Results: Apelin-13 levels were significantly increased in hypertensive patients compared to prehypertensive patients. A significant positive correlation was observed between apelin-13 and oxidized LDL and triglyceride levels. Further, there was no significance observed between other lipid profile parameters.Conclusions: Apelin-13 is a vital factor for assessing endothelial dysfunction in hypertensive patients. Reduction of apelin-13 may be beneficial in preventing vascular complications and coronary heart diseases in hypertensive patients.

Keywords

• apelin-13
• hypertension
• oxidized ldl