Dimeric Pimprinine Alkaloids From Soil-Derived Streptomyces sp. NEAU-C99

Zhiyin Yu; Zhiyin Yu; Hao Jiang; Li Wang; Feng-Xian Yang; Jian-Ping Huang; Chongxi Liu; Chongxi Liu; Xiaowei Guo; Xiaowei Guo; Wensheng Xiang; Sheng-Xiong Huang

doi:10.3389/fchem.2020.00095

Frontiers in Chemistry (Feb 2020)

Dimeric Pimprinine Alkaloids From Soil-Derived Streptomyces sp. NEAU-C99

Zhiyin Yu,
Zhiyin Yu,
Hao Jiang,
Li Wang,
Feng-Xian Yang,
Jian-Ping Huang,
Chongxi Liu,
Chongxi Liu,
Xiaowei Guo,
Xiaowei Guo,
Wensheng Xiang,
Sheng-Xiong Huang

Affiliations

Zhiyin Yu: Heilongjiang Provincial Key Laboratory of Agricultural Microbiology, Northeast Agricultural University, Harbin, China
Zhiyin Yu: State Key Laboratory of Phytochemistry and Plant Resources in West China, CAS Center for Excellence in Molecular Plant Sciences, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China
Hao Jiang: Heilongjiang Provincial Key Laboratory of Agricultural Microbiology, Northeast Agricultural University, Harbin, China
Li Wang: State Key Laboratory of Phytochemistry and Plant Resources in West China, CAS Center for Excellence in Molecular Plant Sciences, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China
Feng-Xian Yang: State Key Laboratory of Phytochemistry and Plant Resources in West China, CAS Center for Excellence in Molecular Plant Sciences, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China
Jian-Ping Huang: State Key Laboratory of Phytochemistry and Plant Resources in West China, CAS Center for Excellence in Molecular Plant Sciences, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China
Chongxi Liu: Heilongjiang Provincial Key Laboratory of Agricultural Microbiology, Northeast Agricultural University, Harbin, China
Chongxi Liu: State Key Laboratory of Phytochemistry and Plant Resources in West China, CAS Center for Excellence in Molecular Plant Sciences, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China
Xiaowei Guo: Heilongjiang Provincial Key Laboratory of Agricultural Microbiology, Northeast Agricultural University, Harbin, China
Xiaowei Guo: State Key Laboratory of Phytochemistry and Plant Resources in West China, CAS Center for Excellence in Molecular Plant Sciences, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China
Wensheng Xiang: Heilongjiang Provincial Key Laboratory of Agricultural Microbiology, Northeast Agricultural University, Harbin, China
Sheng-Xiong Huang: State Key Laboratory of Phytochemistry and Plant Resources in West China, CAS Center for Excellence in Molecular Plant Sciences, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China

DOI: https://doi.org/10.3389/fchem.2020.00095
Journal volume & issue: Vol. 8

Abstract

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Six new pimprinine alkaloids (1–6), including four dimers, dipimprinines A–D (1–4), and two monomers, (±)-Pimprinol D (5), and pimprinone A (6), along with six known congeners (7–12), were isolated from a soil-derived actinomycete Streptomyces sp. NEAU-C99. Structures of the new compounds were elucidated by extensive spectroscopic analyses, single-crystal X-ray diffractions, and ECD calculations. Dipimprinines A–D (1–4) showed weak cytotoxic activities against five tumor cell lines, including HL-60, SMMC-7721, A-549, MCF-7, and SW-480, with IC50 values ranging from 12.7 to 30.7 μM.

Published in Frontiers in Chemistry

ISSN: 2296-2646 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Chemistry
Website: http://journal.frontiersin.org/journal/chemistry

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