Serum Sex Hormone Binding Globulin Concentration as a Predictor of Ovarian Response During Controlled Ovarian Hyperstimulation

Junyu Zhai; Junyu Zhai; Shang Li; Shang Li; Yinci Zhu; Yinci Zhu; Yun Sun; Yun Sun; Zi-Jiang Chen; Zi-Jiang Chen; Zi-Jiang Chen; Zi-Jiang Chen; Zi-Jiang Chen; Yanzhi Du; Yanzhi Du

doi:10.3389/fmed.2021.719818

Frontiers in Medicine (Nov 2021)

Serum Sex Hormone Binding Globulin Concentration as a Predictor of Ovarian Response During Controlled Ovarian Hyperstimulation

Junyu Zhai,
Junyu Zhai,
Shang Li,
Shang Li,
Yinci Zhu,
Yinci Zhu,
Yun Sun,
Yun Sun,
Zi-Jiang Chen,
Zi-Jiang Chen,
Zi-Jiang Chen,
Zi-Jiang Chen,
Zi-Jiang Chen,
Yanzhi Du,
Yanzhi Du

Affiliations

Junyu Zhai: Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Junyu Zhai: Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China
Shang Li: Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Shang Li: Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China
Yinci Zhu: Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Yinci Zhu: Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China
Yun Sun: Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Yun Sun: Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China
Zi-Jiang Chen: Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Zi-Jiang Chen: Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China
Zi-Jiang Chen: Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China
Zi-Jiang Chen: National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, China
Zi-Jiang Chen: Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, China
Yanzhi Du: Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Yanzhi Du: Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China

DOI: https://doi.org/10.3389/fmed.2021.719818
Journal volume & issue: Vol. 8

Abstract

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Purpose: Serum concentrations of sex hormone binding globulin (SHBG), a glycated homodimeric plasma transport protein, correlate positively with the total number of follicles in women with infertility. However, the relationship between serum SHBG concentrations and the ovarian response during controlled ovarian hyperstimulation (COH) and whether this relationship differs between women with and without polycystic ovary syndrome (PCOS) remains unclear.Methods: The study cohort included 120 participants (60 non-PCOS and 60 PCOS) undergoing in vitro fertilization. Serum samples were collected from each participant every 2–3 days during the COH cycle. The concentrations of serum SHBG and other sex hormones were determined to investigate the relationship between serum SHBG concentrations and the ovarian response in women with and without PCOS.Results: We found that the serum SHBG concentration was positively correlated with the ovarian response in non-PCOS patients but not in PCOS patients.Conclusion: The serum SHBG concentration may be clinically useful as a predictor of the ovarian response during COH in patients without PCOS.

Published in Frontiers in Medicine

ISSN: 2296-858X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Medicine (General)
Website: http://www.frontiersin.org/journals/medicine

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