Evidence-based biomaterials research

Kai Zhang; Bin Ma; Kaiyan Hu; Bo Yuan; Xin Sun; Xu Song; Zhonglan Tang; Hai Lin; Xiangdong Zhu; Yufeng Zheng; Andrés J. García; Antonios G. Mikos; James M. Anderson; Xingdong Zhang

Bioactive Materials (Sep 2022)

Evidence-based biomaterials research

Kai Zhang,
Bin Ma,
Kaiyan Hu,
Bo Yuan,
Xin Sun,
Xu Song,
Zhonglan Tang,
Hai Lin,
Xiangdong Zhu,
Yufeng Zheng,
Andrés J. García,
Antonios G. Mikos,
James M. Anderson,
Xingdong Zhang

Affiliations

Kai Zhang: Institute of Regulatory Science for Medical Devices, Sichuan University, Chengdu, 610064, PR China; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610064, PR China; College of Biomedical Engineering, Sichuan University, Chengdu, 610064, PR China; Corresponding author. Institute of Regulatory Science for Medical Devices, Sichuan University, Chengdu, 610064, PR China.
Bin Ma: Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, PR China; Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province, Lanzhou, 730000, PR China; Corresponding author. Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, PR China.
Kaiyan Hu: Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, PR China; Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province, Lanzhou, 730000, PR China
Bo Yuan: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610064, PR China; College of Biomedical Engineering, Sichuan University, Chengdu, 610064, PR China
Xin Sun: Chinese Evidence-based Medicine Centre, West China Hospital, Sichuan University, Chengdu, 610041, PR China
Xu Song: Institute of Regulatory Science for Medical Devices, Sichuan University, Chengdu, 610064, PR China; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610064, PR China; College of Biomedical Engineering, Sichuan University, Chengdu, 610064, PR China
Zhonglan Tang: Institute of Regulatory Science for Medical Devices, Sichuan University, Chengdu, 610064, PR China; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610064, PR China; College of Biomedical Engineering, Sichuan University, Chengdu, 610064, PR China
Hai Lin: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610064, PR China; College of Biomedical Engineering, Sichuan University, Chengdu, 610064, PR China
Xiangdong Zhu: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610064, PR China; College of Biomedical Engineering, Sichuan University, Chengdu, 610064, PR China
Yufeng Zheng: Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing, 100871, PR China
Andrés J. García: Woodruff School of Mechanical Engineering, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, 30332-0363, USA
Antonios G. Mikos: Departments of Bioengineering, Chemical and Biomolecular Engineering, Rice University, Houston, TX, 77251, USA
James M. Anderson: Departments of Pathology, Biomedical Engineering and Macromolecular Science and Engineering, Case Western Reserve University, Cleveland, OH, 44106, USA
Xingdong Zhang: Institute of Regulatory Science for Medical Devices, Sichuan University, Chengdu, 610064, PR China; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610064, PR China; College of Biomedical Engineering, Sichuan University, Chengdu, 610064, PR China

Journal volume & issue: Vol. 15
pp. 495 – 503

Abstract

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The fast development of biomaterials science and engineering has generated significant number of studies and publications as well as tremendous amount of research data. A methodology is needed to translate such research data and results to validated scientific evidence. This article for the first time proposes the concept and methodology of evidence-based biomaterials research, which is to use evidence-based research approach represented by systematic reviews to generate evidence for answering scientific questions related to biomaterials. After briefly introducing the advancement of biomaterials since 1950s, the scientific and engineering nature of biomaterials are discussed along with the roadmap of biomaterials translation from basic research to commercialized medical products, and the needs of scientific evidence. Key information of the evidence-based approach such as its origination from evidence-based medicine, levels of evidence, systematic review and meta-analysis, differences between systematic and narrative reviews is then highlighted. Applications with a step-by-step procedure of conducting evidence-based biomaterials research, three examples of biomaterials research using evidence-based approach to generate scientific evidence, and opportunities and challenges of evidence-based biomaterials research are presented. With its notable impact on the practice of medicine, the evidence-based approach is also expected to make influential contributions to the biomaterials field.

Published in Bioactive Materials

ISSN: 2452-199X (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials; Science: Biology (General)
Website: https://www.keaipublishing.com/en/journals/bioactive-materials/

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