Pain Research and Management (Jan 2008)

A Randomized, Double-Blind, Crossover Comparison of the Efficacy and Safety of Oral Controlled-Release Tramadol and Placebo in Patients with Painful Osteoarthritis

  • Carter Thorne,
  • André D Beaulieu,
  • Denis J Callaghan,
  • William F O’Mahony,
  • John M Bartlett,
  • Richard Knight,
  • Gunnar R Kraag,
  • Ronald Akhras,
  • Paula S Piraino,
  • John Eisenhoffer,
  • Zoltan Harsanyi,
  • Andrew C Darke

DOI
https://doi.org/10.1155/2008/165421
Journal volume & issue
Vol. 13, no. 2
pp. 93 – 102

Abstract

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OBJECTIVE: To compare the efficacy and safety of controlled-release (CR) tramadol (Zytram XL, Purdue Pharma, Canada) and placebo in patients with painful osteoarthritis.