Communications Biology (Aug 2021)
Campylobacter jejuni genotypes are associated with post-infection irritable bowel syndrome in humans
- Stephanie Peters,
- Ben Pascoe,
- Zuowei Wu,
- Sion C. Bayliss,
- Ximin Zeng,
- Adam Edwinson,
- Sakteesh Veerabadhran-Gurunathan,
- Selina Jawahir,
- Jessica K. Calland,
- Evangelos Mourkas,
- Robin Patel,
- Terra Wiens,
- Marijke Decuir,
- David Boxrud,
- Kirk Smith,
- Craig T. Parker,
- Gianrico Farrugia,
- Qijing Zhang,
- Samuel K. Sheppard,
- Madhusudan Grover
Affiliations
- Stephanie Peters
- Department of Gastroenterology and Hepatology, Mayo Clinic
- Ben Pascoe
- The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Claverton Down
- Zuowei Wu
- Department of Veterinary Microbiology and Preventive Medicine, Iowa State University
- Sion C. Bayliss
- The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Claverton Down
- Ximin Zeng
- Department of Gastroenterology and Hepatology, Mayo Clinic
- Adam Edwinson
- Department of Gastroenterology and Hepatology, Mayo Clinic
- Sakteesh Veerabadhran-Gurunathan
- Department of Gastroenterology and Hepatology, Mayo Clinic
- Selina Jawahir
- Minnesota Department of Health
- Jessica K. Calland
- The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Claverton Down
- Evangelos Mourkas
- The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Claverton Down
- Robin Patel
- Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic
- Terra Wiens
- Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic
- Marijke Decuir
- Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic
- David Boxrud
- Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic
- Kirk Smith
- Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic
- Craig T. Parker
- United States Department of Agriculture
- Gianrico Farrugia
- Department of Gastroenterology and Hepatology, Mayo Clinic
- Qijing Zhang
- Department of Veterinary Microbiology and Preventive Medicine, Iowa State University
- Samuel K. Sheppard
- The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Claverton Down
- Madhusudan Grover
- Department of Gastroenterology and Hepatology, Mayo Clinic
- DOI
- https://doi.org/10.1038/s42003-021-02554-8
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 17
Abstract
Stephanie Peters, Ben Pascoe, et al. use whole-genome sequencing and phenotypic analysis of clinical strains from patients to identify potential genetic factors involved in irritable bowel syndrome resulting from Campylobacter jejuni infection. Their data suggest that genes involved in the bacterial stress response and biosynthetic pathways may contribute toward irritable bowel syndrome, providing further insight into links between Campylobacter genotypes and risk of disease.
