Mitigative potentials of methanol leaf extract of Moringa oleifera on chronic carbamazepine-induced haemo-biochemical and thyrotoxicity in male Wistar rats

Abstract

Carbamazepine (CBZ) is commonly used for treating epilepsy and neuropathic pain. This present research was carried out to evaluate ameliorative potentials of methanol leaves extract of Moringa oleifera on chronic CBZ-induced haemotoxicity and thyrotoxicosis in male Wistar rats.32 adult male Wistar rats were divided into four groups of 8 animals each and exposed to the following regimens: Group I (DW) was administered distilled water (2 ml/kg); group II (MO) was exposed M. oleifera (200 mg/kg); group III (CBZ) was given carbamazepine at 20 mg/kg, while group IV (CBZ+MO) was exposed to carbamazepine (20 mg/kg) then followed by M. oleifera (200 mg/kg) 30 minutes later. The regimens were given once daily for 15 weeks via gavage. Blood and serum samples were evaluated for haematological parameters, liver biochemical enzymes and thyroid hormone.The results revealed that M. oleifera leaves extract mitigate against alteration in parameters measuring haematological, biochemical and thyroid functions.The study concluded that amelioration against CBZ-evoked alteration in haematological indices, biochemical enzymes and thyroid function by M. oleifera leave extract was partly due to its nutritional values and phytochemical constituents that confer protection on blood vascular system, and hypothalamic-pituitary axis.

Keywords

• Chronic exposure
• carbamazepine
• haemotoxicity
• thyrotoxicosis
• Moringa oleifera