Synthesis of Bis(3‐indolyl)methanes Mediated by Potassium tert‐Butoxide

Abstract

Abstract The indole moiety is an important N‐heterocycle found in natural products, and a key structural component of many value‐added chemicals including pharmaceuticals. In particular, bis(3‐indolyl)methanes (BIMs) are an important subgroup of indoles, composed of two indole units. Herein, we report the development of a simple method to access BIMs derivatives in yields of up to 77 % by exploiting a tBuOK‐mediated coupling reaction of indoles and benzyl alcohols.

Keywords

• bis(indolyl)methanes
• indole
• tBuOK
• radicals
• benzyl alcohols