The structural flexibility of MAD1 facilitates the assembly of the Mitotic Checkpoint Complex

Chu Chen; Valentina Piano; Amal Alex; Simon J. Y. Han; Pim J. Huis in ’t Veld; Babhrubahan Roy; Daniel Fergle; Andrea Musacchio; Ajit P. Joglekar

doi:10.1038/s41467-023-37235-z

Nature Communications (Mar 2023)

The structural flexibility of MAD1 facilitates the assembly of the Mitotic Checkpoint Complex

Chu Chen,
Valentina Piano,
Amal Alex,
Simon J. Y. Han,
Pim J. Huis in ’t Veld,
Babhrubahan Roy,
Daniel Fergle,
Andrea Musacchio,
Ajit P. Joglekar

Affiliations

Chu Chen: Biophysics, University of Michigan
Valentina Piano: Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology
Amal Alex: Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology
Simon J. Y. Han: Cell and Developmental Biology, University of Michigan Medical School
Pim J. Huis in ’t Veld: Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology
Babhrubahan Roy: Cell and Developmental Biology, University of Michigan Medical School
Daniel Fergle: Cell and Developmental Biology, University of Michigan Medical School
Andrea Musacchio: Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology
Ajit P. Joglekar: Biophysics, University of Michigan

DOI: https://doi.org/10.1038/s41467-023-37235-z
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 11

Abstract

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The formation of the mitotic checkpoint complex requires an intricate spatial coordination amongst the proteins Bub1, Mad1, Cdc20, and Mad2. Chen et al show that a structural flexibility in Mad1 plays an essential role in achieving this coordination.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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