Nature Communications (May 2018)
Whole-genome sequencing reveals genomic signatures associated with the inflammatory microenvironments in Chinese NSCLC patients
- Cheng Wang,
- Rong Yin,
- Juncheng Dai,
- Yayun Gu,
- Shaohua Cui,
- Hongxia Ma,
- Zhihong Zhang,
- Jiaqi Huang,
- Na Qin,
- Tao Jiang,
- Liguo Geng,
- Meng Zhu,
- Zhening Pu,
- Fangzhi Du,
- Yuzhuo Wang,
- Jianshui Yang,
- Liang Chen,
- Qianghu Wang,
- Yue Jiang,
- Lili Dong,
- Yihong Yao,
- Guangfu Jin,
- Zhibin Hu,
- Liyan Jiang,
- Lin Xu,
- Hongbing Shen
Affiliations
- Cheng Wang
- Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University
- Rong Yin
- Department of Thoracic Surgery, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Jiangsu Key Laboratory of Molecular and Translational Cancer Research
- Juncheng Dai
- Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University
- Yayun Gu
- Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University
- Shaohua Cui
- Department of Respiratory Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University
- Hongxia Ma
- Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University
- Zhihong Zhang
- Department of Pathology, First Affiliated Hospital, Nanjing Medical University
- Jiaqi Huang
- Cellular Biomedicine Group, Inc.
- Na Qin
- Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University
- Tao Jiang
- Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University
- Liguo Geng
- Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University
- Meng Zhu
- Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University
- Zhening Pu
- Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University
- Fangzhi Du
- Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University
- Yuzhuo Wang
- Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University
- Jianshui Yang
- Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University
- Liang Chen
- Department of Thoracic Surgery, First Affiliated Hospital, Nanjing Medical University
- Qianghu Wang
- Department of Bioinformatics, School of Biomedical Engineering and Informatics, Nanjing Medical University
- Yue Jiang
- Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University
- Lili Dong
- Department of Respiratory Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University
- Yihong Yao
- Cellular Biomedicine Group, Inc.
- Guangfu Jin
- Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University
- Zhibin Hu
- Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University
- Liyan Jiang
- Department of Respiratory Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University
- Lin Xu
- Department of Thoracic Surgery, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Jiangsu Key Laboratory of Molecular and Translational Cancer Research
- Hongbing Shen
- Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University
- DOI
- https://doi.org/10.1038/s41467-018-04492-2
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 10
Abstract
The distinct genomic and epidemiological features of Chinese lung cancer patients suggest the presence of alternative causal mechanisms. Here, the authors present the genomic landscape of 149 Chinese NSCLC patients and reveal distinct mutational signatures associated with inflammatory microenvironments.
