Progress in application of Bcl-2 in repairment of the optic nerve injury

Abstract

Bcl-2 is a proto-oncogene isolated from follicular B cells, and it is closely related to cell apoptosis. In recent years, it has been widely used in experiments to repair central nervous injury, especially the optic nerve injury. In some cases, it is found that Bcl-2 can inhibit cell apoptosis, prolong cell life span, but can not promote cell proliferation. In other cases, it can not prevent apoptosis caused by certain genetic mutations and thus cannot protect the optic nerve.

Keywords

• optic nerve injury
• anti-apoptosis
• application