Foxp3+ regulatory T cells maintain the bone marrow microenvironment for B cell lymphopoiesis

Antonio Pierini; Hidekazu Nishikii; Jeanette Baker; Takaharu Kimura; Hye-Sook Kwon; Yuqiong Pan; Yan Chen; Maite Alvarez; William Strober; Andrea Velardi; Judith A. Shizuru; Joy Y. Wu; Shigeru Chiba; Robert S. Negrin

doi:10.1038/ncomms15068

Nature Communications (May 2017)

Foxp3+ regulatory T cells maintain the bone marrow microenvironment for B cell lymphopoiesis

Antonio Pierini,
Hidekazu Nishikii,
Jeanette Baker,
Takaharu Kimura,
Hye-Sook Kwon,
Yuqiong Pan,
Yan Chen,
Maite Alvarez,
William Strober,
Andrea Velardi,
Judith A. Shizuru,
Joy Y. Wu,
Shigeru Chiba,
Robert S. Negrin

Affiliations

Antonio Pierini: Department of Medicine, Division of Blood and Marrow Transplantation, Stanford University
Hidekazu Nishikii: Department of Medicine, Division of Blood and Marrow Transplantation, Stanford University
Jeanette Baker: Department of Medicine, Division of Blood and Marrow Transplantation, Stanford University
Takaharu Kimura: Department of Medicine, Division of Endocrinology, Stanford University of Medicine
Hye-Sook Kwon: Department of Medicine, Division of Blood and Marrow Transplantation, Stanford University
Yuqiong Pan: Department of Medicine, Division of Blood and Marrow Transplantation, Stanford University
Yan Chen: Department of Medicine, Division of Blood and Marrow Transplantation, Stanford University
Maite Alvarez: Department of Medicine, Division of Blood and Marrow Transplantation, Stanford University
William Strober: Department of Medicine, Division of Blood and Marrow Transplantation, Stanford University
Andrea Velardi: Department of Medicine, Hematopoietic Stem Cell Transplantation Program, University of Perugia, Piazzale Menghini, 06132, Sant’Andrea delle Fratte
Judith A. Shizuru: Department of Medicine, Division of Blood and Marrow Transplantation, Stanford University
Joy Y. Wu: Department of Medicine, Division of Endocrinology, Stanford University of Medicine
Shigeru Chiba: Department of Hematology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai
Robert S. Negrin: Department of Medicine, Division of Blood and Marrow Transplantation, Stanford University

DOI: https://doi.org/10.1038/ncomms15068
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 13

Abstract

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Treg cells suppress peripheral immune responses, but their function in haematopoiesis is unclear. Here the authors show they modulate the bone marrow microenvironment to sustain haematopoietic stem cell-driven generation of mature B cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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