RISK FACTORS OF CORONARY ARTERIES RESTENOSIS AFTER STENTING IN POSTMENOPAUSAL WOMEN WITH OBESITY

Abstract

Aim. To assess the preoperational risk factors (RF) most significantly related to coronary arteries (CA) restenosis in postmenopausal women with obesity.Material and methods. To the study, 94 women included, age 44-70 y.o. (55,44±6,3 y.o.) with obesity of I-III grade by WHO (2003), and CHD: stable angina II-IV functional class, with indicated stenting of one of CA. Group 1 (n=19) consisted of restenosis patients with restenosis in the zone CA stenting; group 2 (n=65) — no restenosis and no other cardiovascular complications (CVC). In the comparison groups, analysis of the main and additional RF was done, and with the logistic regression — search for the most adverse RF combination related to CA restenosis in women with obesity and post-menopause.Results. In the group 1 patients, during the post-surgery period, the highest levels of glucose were found (р=0,044), of blood insulin (р=0,036), index HOMA-IR (р=0,052), lipoprotein^) (р=0,003), interleukin-6 (р=0,003), tumor necrosis factor а (р=0,001), leptin (р=0,003), and older age (p=0,01). Most adverse RF combination related to CA restenosis, were epicardial fat tissue thickness, insulin and age.Conclusion. The revealed RF combination makes it to select most perspective and rational schemes of medication and non-medication prevention of CA restenosis. The data is a worthy material for further research on the roles of neurohumoral and pro-inflammatory activity of visceral fat tissue in CVC risk in obesity patients.

Keywords

• obesity
• coronary restenosis
• menopause
• risk factors